化合物 MmpL3-IN-1|T61303|TargetMol

MmpL3-IN-1

￥10600 25mg 起订

￥17500 100mg 起订

￥13800 50mg 起订

上海更新日期：2025-11-17

TargetMol中国（陶术生物）

VIP2年

联系人：邵小姐

手机：15002134094 拨打

邮箱：marketing@targetmol.cn

产品详情:

中文名称：: 化合物 MmpL3-IN-1

英文名称：: MmpL3-IN-1

CAS号：: 2290534-93-7

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

产品类别：: 抑制剂

货号：: T61303

Product Introduction

Bioactivity

名称	MmpL3-IN-1
描述	MmpL3-IN-1, also known as compound 32, is a highly effective inhibitor of Mycobacterial membrane protein large 3 (MmpL3). With an anti-tuberculosis activity exhibiting a minimum inhibitory concentration (MIC) of less than 0.016 μg/mL in M. tuberculosis, MmpL3-IN-1 is a valuable compound for research on drug-resistant tuberculosis [1].
体外活性	MmpL3-IN-1 (compound 32) (0.26-64 μg/mL, 2-7days) has potent anti- M. tuberculosis activity with the MIC value of less than 0.016 μg/mL and with almost non-toxic to Vero cells [1]. MmpL3-IN-1 has good microsomal stability and little inhibition of hERG K + channels with the IC 50 value of more than 30 μM [1]. MmpL3-IN-1 (0.0625-1 μg/mL, 16 h) can inhibit TMM transport by targeting MmpL3, thereby affecting the formation of the cell wall of M. tuberculosis [1]. Cell Viability Assay [1] Cell Line: Vero cells Concentration: 0.26-64 μg/mL Incubation Time: 48 hours Result: Inhibited cell viability with an IC 50 value of 35.3 μg/mL. Western Blot Analysis [1] Cell Line: M. tuberculosis H37Rv mc 2 6206 Concentration: 0.0625-1 μg/mL Incubation Time: 16 hours Result: Resulted in the accumulation of alginate monomycin (TMM) expression and reduced cell wall-bound mycolic acid methyl esters (MAMEs) in a dose-dependent manner. Reduced synthesis of alginate dimycolate (TDM), together with accumulation of free mycolate at high concentration.
体内活性	MmpL3-IN-1 (compound 32) (oral gavage, 100 mg/kg, 5 days per week, 30 days) has effective anti-tuberculosis activity in SPF BALB/c female mice with H37Rv [1]. Animal Model: SPF BALB/c female mice with H37Rv [1] Dosage: 100 mg/kg Administration: Oral gavage; 5 days per week; 30 days Result: Showed a 2.0 log CFU reduction of H37Rv in lung colony forming units. Animal Model: BALB/c mouse (female) weighing 20-25 g [1] Dosage: Administration: 100 mg/kg p.o. or 10 mg/kg i.v.; 0-24 hours Result: b>The pharmacokinetic parameters of MmpL3-IN-1 (compound 32) Parameter iv, 10 mg/kg po, 100 mg/kg t 1/2 (h) 7.37 7.48 C max (ng/mL) 5105 211 T max (h) 0.03 0.5 AUC 0-t (h ng/mL) 2475 1625 MRT 0-t (h ng/mL) 2.00 8.69 V (mL/kg) 42067 - CL (mL/h/kg) 3958 - F% - 6.6
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
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MmpL3-IN-1|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(13年)
注册资本	589.8595万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	中间体,天然产物,生物化工,化学试剂,生物技术服务

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