司替帕泛|T16874|TargetMol

Setipafant
132418-35-0

￥18300 50mg 起订

￥23500 100mg 起订

￥13900 25mg 起订

上海更新日期：2026-06-29

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 司替帕泛

英文名称：: Setipafant

CAS号：: 132418-35-0

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

产品类别：: 抑制剂

货号：: T16874

Product Introduction

Bioactivity

名称	Setipafant
描述	Setipafant is an antagonist of the platelet-activating factor.
体内活性	Pretreatment of the animals with one or other of the structurally unrelated PAF receptor antagonists, BN 52021 (10 mg/kg, i.p.) or Setipafant (1 mg/kg, i.p.) significantly decreases Dexamethasone-induced gastric damage. Animals are separated into six groups: U4, controls; S, sham-operated animals undergoing laparotomy; I4 and I9, ligation of the mesenteric vessels in the last ileal loop; IT4 and IT9, same procedure together with treatment with Setipafant (50 mg/kg) orally before and after surgery and intraperitoneally during surgery. Animals are killed at day 4 in groups U4, S, I4, and IT4 and on day 9 in groups I9 and IT9, with histological studies and mediator measurements taken. Macroscopic and histological lesions of the intestinal wall in groups I4, I9, IT4, and IT9 are similar to those of human neonatal necrotizing enterocolitis and do not vary according to the absence or the presence of Setipafant treatment. Peritoneal bands are significantly reduced in treated groups IT4 and IT9 as compared with untreated ones I4 and I9. Mucosal PAF levels in the terminal ileum are higher in group I4 than in groups U4 or I9. In the upper loop, mucosal PAF levels are comparable in all groups. An increase in stool PAF levels is observed only in group I9, whereas values comparable to those observed in controls are detected in other groups [1][2].
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
关键字	Setipafant \| PAF \| LAU0901 \| LAU 0901 \| BN50727 \| BN 50727
相关产品	48740 RP \| Rupatadine Fumarate \| Rupatadine \| Cedrol \| SDZ-62-434 \| Ginkgolide B \| PAF C-18 \| Dersalazine \| (Rac)-Modipafant \| CP 96021 \| 2-Acetylbenzoic acid \| Rocepafant

司替帕泛|||LAU-0901|||BN-50727|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(14年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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