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网站主页 Abacavir (sulfate) 化合物 Abacavir monosulfate
  • 化合物 Abacavir monosulfate|T61679|TargetMol

化合物 Abacavir monosulfate|T61679|TargetMol

Abacavir monosulfate
216699-07-9
￥1080 5mg 起订
￥2130 10mg 起订
￥4880 25mg 起订
上海 更新日期：2025-11-17

TargetMol中国（陶术生物）

VIP4年
联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
化合物 Abacavir monosulfate
英文名称：
Abacavir monosulfate
CAS号：
216699-07-9
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
产品类别：
抑制剂
货号：
T61679

Product Introduction

Bioactivity

名称Abacavir monosulfate
描述Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, and has the ability to penetrate the blood-brain-barrier and suppress telomerase activity [1] [2] [3].
体外活性Abacavir (15 and 150 μM, 0-120 h) monosulfate inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines [1]. Abacavir (15 and 150 μM, 18 h) monosulfate significantly reduces cell migration and inhibits cell invasion [1]. Abacavir monsulfate induces fat apoptosis [4]. Cell Proliferation Assay [1] Cell Line: PC3, LNCaP and WI-38 Concentration: 15 and 150 μM Incubation Time: 0, 24, 48, 72 and 96 h Result: Showed a dose-dependent growth inhibition on PC3 and LNCaP. Cell Cycle Analysis [1] Cell Line: PC3 and LNCaP Concentration: 150 μM Incubation Time: 0, 18, 24, 48, 72, 96 and 120 h Result: Caused a very high accumulation of cells in S phase in PC3 and LNCaP cells, and G2/M phase increment was observed in PC3 cells. Cell Migration Assay [1] Cell Line: PC3 and LNCaP Concentration: 15 and 150 μM Incubation Time: 18 h Result: Significantly reduced cell migration. Cell Invasion Assay [1] Cell Line: PC3 and LNCaP Concentration: 15 and 150 μM Incubation Time: 18 h Result: Significantly inhibited cell invision.
体内活性Abacavir (0-7.5 μg/mL, 100 μL, intrascrotal administration; 100 and 200 mg/kg, p.o.; 4 h) monosulfate dose-dependently promoted thrombus formation [2]. Abacavir (50 mg/kg/d; i.p.; 14 days) monosulfate with 0.1 mg/kg/d Decitabine enhances survival of high-risk medulloblastoma-bearing mice [3]. Animal Model: Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7 tm1Gab /J) [2] Dosage: 2.5, 5 and 7.5 μg/mL, 100 μL or 100 and 200 mg/kg Administration: Intrascrotal or oral administration for 4 h Result: Dose-dependently promoted thrombus formation. Animal Model: NSG TM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma [3] Dosage: 50 mg/kg/d with 0.1 mg/kg/d Decitabine Administration: Intraperitoneal injection, daily for 14 days Result: Inhibited tumor growth and enhanced mouse survival.
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
相关产品L-Methionine | Cysteamine hydrochloride | Alginic acid | Emtricitabine | Metronidazole | Dextran sulfate sodium salt (MW 5000) | Lamivudine | Citric Acid Triammonium | Stavudine | Cystamine dihydrochloride | L-Ascorbic acid sodium salt | Sodium 4-phenylbutyrate
Abacavir monosulfate|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (13年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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