SCR7 吡嗪|T1724|TargetMol

SCR7 pyrazine
14892-97-8

￥286 1mg 起订

￥397 2mg 起订

￥672 5mg 起订

上海更新日期：2024-09-30

TargetMol中国（陶术生物）

VIP3年

联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: SCR7 吡嗪

英文名称：: SCR7 pyrazine

CAS号：: 14892-97-8

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.85%

产品类别：: 抑制剂

货号：: T1724

Product Introduction

Bioactivity

Name	SCR7 pyrazine
Description	SCR7 pyrazine (SCR7) enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ).
Cell Research	Cell proliferation of cancer cells are determined by MTT and trypan blue assays. Briefly, MCF7, CEM, HeLa, A549, HT1080, A2780, T47D, Nalm6, N114 and K562 cells are grown in presence of SCR7 (10, 50, 100, and 250?μM) for 24 or 48?h, and subjected to MTT or trypan blue assays. Each experiment is repeated a minimum of three independent times. (Only for Reference)
Kinase Assay	Complementation of SCR7 Inhibition with Puri?ed Ligase IV: Complementation experiment is carried out by adding increasing concentrations of puri?ed Ligase IV/XRCC4 complex (30, 60, and 120 fmol) along with the oligomeric DNA substrates (5' compatible and 5'-5' noncompatible ends) to the SCR7-treatedextracts. Reactions are incubated for 2 h at 25℃. The reaction products are then resolved on 8% denaturing PAGE. The gel is dried and exposed and the signal is detected with a PhosphorImager and analyzed with Multi Gauge (V3.0) software.
In vitro	SCR7在200μM及以上浓度下有效抑制多聚体的形成。SCR7成功抑制了MCF7、A549、HeLa、T47D、A2780、HT1080和Nalm6细胞的增殖，其IC50分别为40、34、44、8.5、120、10和50μM。[1] SCR7抑制了CRISPR-Cas9诱导的DSBs的NHEJ修复。[2]
In vivo	SCR7处理（10 mg/kg，肌肉注射）显著减少了乳腺腺癌诱导的肿瘤，并且与对照组相比，生命期增加了4倍。然而，在携带Dalton's淋巴瘤肿瘤模型的瑞士白鼠中，SCR7（20 mg/kg，腹腔注射）既不表现出肿瘤退缩也不增加生命期。在BALB/c小鼠中，SCR7（20 mg/kg，腹腔注射）显著增强了辐射、依托泊苷和3-氨基苯甲酰胺对源自Dalton's淋巴瘤（DLA）细胞的肿瘤的细胞毒作用。[1]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 3 mg/mL (9.03 mM) DMSO : 66 mg/mL (198.57 mM)
Keywords	SCR-7 pyrazine \| Caspase 9 \| Apoptosis \| ligase-IV \| nonhomologous \| Caspase 3 \| SCR-7 \| DNA \| SCR7 pyrazine \| Inhibitor \| SCR 7 \| replacement \| anticancer \| gene \| end-joining \| phosphorylation \| DNA/RNA Synthesis \| inhibit \| CRISPR/Cas9
Inhibitors Related	Guanidine hydrochloride \| Metronidazole \| 5-Fluorouracil \| Stavudine \| Tributyrin \| Dextran sulfate sodium salt (MW 4500-5500) \| L-Ascorbic acid \| Thymidine \| Sodium 4-phenylbutyrate
Related Compound Libraries	Inhibitor Library \| Bioactive Compound Library \| Anti-Cancer Active Compound Library \| Anti-Cancer Compound Library \| Bioactive Compounds Library Max \| Cell Cycle Compound Library \| Apoptosis Compound Library \| Anti-Aging Compound Library \| DNA Damage & Repair Compound Library \| Target-Focused Phenotypic Screening Library

SCR7 吡嗪|||SCR7|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

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