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网站主页 MK-571 SODIUM HYDRATE 化合物 Propanoic acid
  • 化合物 Propanoic acid|T3148|TargetMol

化合物 Propanoic acid|T3148|TargetMol

MK-571 sodium
115103-85-0
￥275 1mg 起订
￥627 5mg 起订
￥995 10mg 起订
上海 更新日期：2024-12-12

TargetMol中国（陶术生物）

VIP3年
联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
化合物 Propanoic acid
英文名称：
MK-571 sodium
CAS号：
115103-85-0
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格：
98.69%
产品类别：
抑制剂
货号：
T3148

Product Introduction

Bioactivity

名称MK-571 sodium
描述MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the cellular efflux of drugs, xenobiotics, and their conjugates. MK-571 sodium can inhibit the synthesis of K-4′-O-GlcA (19.7 μM). MK571 dose-dependently inhibits the intracellular biosynthesis of all flavonol sulphates and glucuronides by Caco-2 cells. MK-571 sodium significantly inhibits phase-2 conjugation of kaempferol by cell-free extracts of Caco-2, and production of kaempferol-4′-O-glucuronide was competitively inhibited. In addition to inhibiting MRP2, MK571 is a potent inhibitor of enterocyte phase-2 conjugation.
细胞实验Cells were seeded onto 96 well plates at a concentration of 1×103 cells per well and incubated for 72 h at 37?C and 5% CO2 to allow MRP1 messenger RNA suppression to occur. Cells were then treated with either control media or one of three chemotherapy drugs temozolomide (150 µM), vincristine (100 nM), or etoposide (2 µM). Cells were then returned to the incubator for a further 72 h; after which time, Metylthiazol Tetrazolium (MTT) powder in PBS (50µl of 5 mg/ml) was added to each well. Cells were then incubated for a further 4 h after which all solution was removed and dimethyl sulfoxide (DMSO) was added. After 10 min incubation time at 37?C, absorbance was recorded at 570 nm wavelength and data was recorded and analyzed. Small molecule inhibitors MK571 (25 µM) and Reversan (15µM) were added 7 h prior to carrying out further drug treatment (temozolomide, vincristine or etoposide) or assay assessment (media change for proliferation and 2D-migration assays) (Only for Reference)
体外活性MK-571在健康年轻人体内耐受性良好.口服可被迅速吸收,血药浓度在给药后1.1-1.5 h后达峰.
体内活性在类肺部,MK-571可抑制[3H]LTD4的结合（Ki：2.1±1.8 nM,n=29）,而在豚鼠肺中的Ki值为0.22±0.15 nM (n=35)。但其对[3H]LTC4的结合活性较低或没有活性（IC50：32 μM,n=1,人；23±11 μM,n=16,豚鼠）。
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 25.78 mg/mL (48 mM), Sonication and heating are recommended.
Ethanol : Insoluble
关键字L 660711 | MRP4 | MK-571 | Lysophospholipid Receptor | human mast cells | LAD2 | MK 571 sodium | MRP1 | Leukotriene Receptor | sphingosine kinase | L-660711 sodium | ABCC1 | LPL Receptor | bronchoconstriction | Sphingolipids | Inhibitor | L660711 | ATP-binding cassette | pulmonary hypertension | MK-571 sodium | inhibit | dyspnea | MK 571 | MK571 sodium | RBL-2H3 cells
相关产品Tebufelone | L 674573 | ABT-080 | Bestatin | Montelukast sodium | LTB4-IN-1 | Croconazole | Linetastine | LTβR-IN-1 | CGP 35949 | Ticolubant | Moxilubant HCl
相关库抑制剂库 | 经典已知活性库 | 已知活性化合物库 | 凝血与抗凝化合物库 | GPCR靶点分子库 | 临床期小分子药物库 | 膜蛋白靶向化合物库 | 药物功能重定位化合物库 | 抗癌临床化合物库 | 抗癌药物库
Verlukast sodium|||Propanoic acid|||MK-571 sodium salt|||MK571|||L-660711 sodium salt|||L-660711 (sodium salt)|||L-660711|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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