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网站主页 化工产品目录 生物化工 生化试剂 激动剂抑制剂 N-6-异喹啉基-N'-[2-氧代-2-(1-吡咯烷基)乙基]脲 化合物 SGC707
  • 化合物 SGC707|T3084|TargetMol

化合物 SGC707|T3084|TargetMol

SGC707
1687736-54-4
￥164 1mg 起订
￥332 5mg 起订
￥534 10mg 起订
上海 更新日期：2024-09-30

TargetMol中国（陶术生物）

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联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
化合物 SGC707
英文名称：
SGC707
CAS号：
1687736-54-4
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格：
99.75%
产品类别：
抑制剂
货号：
T3084

Product Introduction

Bioactivity

NameSGC707
DescriptionSGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.
Cell ResearchCells are seeded in 96-well plates and treated with different concentrations of SGC707 for 72 h. Cell viability is determined using Alamar blue 0.01 mg/mL in the media. Resazurin reduction is monitored with 544 nm excitation, measuring fluorescence at 590 nm. (Only for Reference)
Kinase AssayPRMT3 biochemical assay: A radioactivity-based assay is optimized and used to determine the inhibition of PRMT3 in vitro. In a scintillation proximity assay (SPA), tritiated S-adenosylmethionine (3H-SAM) served as a methyl donor to methylate biotinylated histone peptide substrate. After completion of the reaction, the reaction mixture is transferred to the wells of a streptavidin / scintillant-coated microplate. The Biotinylated peptides binding to streptavidin coated resin, brings the incorporated 3H-methyl and the scintillant to close proximity. The amount of methylated peptide is quantified by tracing the radioactivity (counts per minute) as measured by the TopCount NXT? Microplate Scintillation and Luminescence Counter. Due to the very acidic nature of the 3H-SAM solution, non-tritiated (cold) SAM is used to supplement the reactions. The C-terminally biotinylated peptide composed of the first 24 amino acids residues of histone H4 (H4 1-24) is used as substrate. The typical assay mixture contained 0.01% Tween-20, 5 mM DTT, 20 nM PRMT3, 0.3 μM B-H4 1-24 and 28 μM (5 μM 3H-SAM plus 23 μM cold SAM) SAM in 20 mM Tris-HCl (pH 7.5) and a final volume of 20 μL. The IC50 values are determined at Km concentrations of both substrates by titration of the compound in the reaction mixture in a range between 2000-0.2 nM.
In vitro在细胞中，SGC707与PRMT3结合，并降低PRMT3依赖性的H4R3me2a。SGC707还能在HEK293和A549细胞中稳定PRMT3，其EC50值分别为1.3 μM和1.6 μM。[1]
In vivo在CD-1雄性小鼠中，SGC707（30 mg/kg，i.p.）在6小时内展现了良好的血浆暴露度，峰值血浆浓度达到38000 nM，这表明SGC707适用于动物研究。[1]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationEthanol : 55 mg/mL (184.4 mM)
DMSO : 50 mg/mL (167.59 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Keywordsinhibit | Inhibitor | SGC707 | Histone Methyltransferase | SGC 707 | SGC-707
Inhibitors RelatedTazemetostat hydrobromide | XY1 | BML-278 | MRTX-1719 | MAK683 | GSK126 | Tazemetostat | EPZ015666 | UNC 0631 | AMI-1 free acid | MS37452 | Piribedil
Related Compound LibrariesInhibitor Library | Bioactive Compound Library | Bioactive Compounds Library Max | Chromatin Modification Compound Library | Anti-Aging Compound Library | NO PAINS Compound Library | Stem Cell Differentiation Compound Library | Covalent Inhibitor Library | Methylation Compound Library | Reprogramming Compound Library
SGC707|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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