化合物 UNC1215|T2379|TargetMol

UNC1215
1415800-43-9

￥245 1mg 起订

￥329 2mg 起订

￥496 5mg 起订

上海更新日期：2025-07-28

TargetMol中国（陶术生物）

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联系人：邵小姐

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产品详情:

中文名称：: 化合物 UNC1215

英文名称：: UNC1215

CAS号：: 1415800-43-9

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

产品类别：: 抑制剂

货号：: T2379

Product Introduction

Bioactivity

名称	UNC1215
描述	UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold higher versus other members of the human MBT family.
细胞实验	CellTiter-Glo luminescent cell viability assay(Only for Reference)
激酶实验	AlphaScreen assay: Compound plates (1 μL at 10 or 30 mM highest concentration) are diluted in 1×assay buffer (20 mM Tris pH 8.0, 25 mM NaCl, 2 mM DTT and 0.05% Tween-20) over 2 steps using a Multimek robotic pipettor and 1 μL is spotted into the wells of 384-well assay Proxiplates. To these plates 9 μL of protein- peptide mix in 1× assay buffer is added by Multidrop and incubated for 30 min at room temperature. At this point 2 μL of streptavidin-conjugate donor and nickel-chelate acceptor beads (45 μg/mL in 1× assay buffer) are added, the plates are allowed to incubate for an additional 30 min in the dark at room temperature. After incubation the plates are read on EnVision mulilabel reader equipped with HTS alpha screen laser. The screens reported are performed up to 10 or 30 μM, and therefore it should be noted that those compounds referred to as inactive are indeed inactive only within the concentration range tested. PHF23 and JARID1A are GST tagged and consequently for these assays GST-acceptor beads are used. It should be noted that any positive binding curves for L3MBTL4 that are generated yielded curves with very shallow slopes, suggesting a nonspecific interaction. The data for the IC50 values is calculated from replicate runs in that the datapoints for each compound concentration are averaged and plotted using 4-parameters curve fitting.
体内活性	UNC1215与L3MBTL3结合,竞争性置换含单或二甲基赖氨酸的肽段。UNC1215对L3MBTL3的选择性比L3MBTL1高约75倍。UNC1215无细胞毒性,通过MBT域的Kme结合口袋,直接结合到L3MBTL3。UNC1215使GFP-L3MBTL3融合蛋白的细胞移动性与点突变增加,干扰GFP-L3MBTL3表型模拟的Kme结合功能,影响UNC1215的定位。UNC1215（30 μM）不影响UHRF1的串联Tudor域、CBX7的染色质域及JARID1A的PHD域。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	DMSO : 93 mg/mL (175.56 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 93 mg/mL (175.56 mM), Sonication is recommended.
关键字	UNC-1215 \| UNC1215 \| UNC 1215 \| probe \| methyllysine \| MBT \| Malignant \| L3MBTL3-D274A \| L3MBTL3 \| Inhibitor \| inhibit \| HistoneMethyltransferase \| Histone Methyltransferase \| EpigeneticReaderDomain \| Epigenetic Reader Domain \| Cerebrum \| Apoptosis
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TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

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