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  • SDF-1/CXCL12, Mouse, 重组蛋白|TMPJ-00952|TargetMol

SDF-1/CXCL12, Mouse, 重组蛋白|TMPJ-00952|TargetMol

SDF-1/CXCL12 Protein, Mouse, Recombinant
17400 1mg 起订
上海 更新日期:2024-09-30

TargetMol中国(陶术生物)

VIP1年
联系人:邵小姐
手机:15002134094 拨打
邮箱:marketing@targetmol.cn

产品详情:

中文名称:
SDF-1/CXCL12, Mouse, 重组蛋白
英文名称:
SDF-1/CXCL12 Protein, Mouse, Recombinant
品牌:
TargetMol
产地:
美国
保存条件:
store at low temperature | Lyophilized powder: -20~-80°C for 1 year | Shipping with blue ice.
纯度规格:
> 99.9%
产品类别:
抑制剂
货号:
TMPJ-00952

Product Introduction

Bioactivity

名称SDF-1/CXCL12 Protein, Mouse, Recombinant
描述Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, and lymphoid organs. Cxcl12 activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. It also binds to atypical chemokine receptor ACKR3 which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Cxcl12 has several critical functions during embryonic development such as B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Cxcl12 plays an important role in acting as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. It stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. It also plays a protective role after myocardial infarction, induces down-regulation and internalization of ACKR3 expressed in various cells and stimulates the proliferation of bone marrow-derived b progenitor cells in the presence of IL-7 as well as growth of the stromal cell-dependent B-cell clone DW34 cells.
存储条件store at low temperature | Lyophilized powder: -20~-80°C for 1 year | Shipping with blue ice.
关键字TPAR-1 | SDF 1 | TPAR 1 | SDF1
Sdf1|||C-X-C motif chemokine 12|||Thymic lymphoma cell-stimulating factor|||Cxcl12|||12-O-tetradecanoylphorbol 13-acetate repressed protein 1|||PBSF|||SDF-1|||TPAR1|||Stromal cell-derived factor 1|||TLSF|||Pre-B cell growth-stimulating factor|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿,致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区,已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库,以及多种类型的生化试剂产品,包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等,此外,我们还建设有CADD(计算机辅助药物设计)研究中心、药理实验室、药化合成平台三大技术中心,全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持,我们将有效帮助您缩短研发周期,取得更成功的结果。

成立日期 (12年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ¥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,天然产物,生物化工,化学试剂,生物技术服务

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