化合物 EGT1442|T7217|TargetMol

Bexagliflozin
1118567-05-7

￥477 1mg 起订

￥690 2mg 起订

￥987 5mg 起订

上海更新日期：2024-09-30

TargetMol中国（陶术生物）

VIP3年

联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 EGT1442

英文名称：: Bexagliflozin

CAS号：: 1118567-05-7

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 98.99%

产品类别：: 抑制剂

货号：: T7217

Product Introduction

Bioactivity

名称	Bexagliflozin
描述	Bexagliflozin (EGT1442) is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively
动物实验	Prior to experiment initiation, 7-week old SHRSP rats were assigned to 3 groups of 15 males each, based on body weights. During this week, daily water consumption was determined in order to calculate appropriate drug concentrations for the drinking water. The following week (Day 1), rats were switched to a stroke-promoting diet containing reduced potassium and protein and elevated NaCl. Animals received water bottles containing either no compound, EGT1442 (3.0 mg/kg) or the sodium channel blocker amiloride (1.0 mg/kg). Body weights were measured 2 times per week, and dosages were adjusted weekly. Water consumption was likewise measured 2 times per week, while food consumption wasmeasured weekly. Daily values were estimated. Urine samples were analyzed by test strips once every two weeks. Additionally, all animals were observed twice daily and any abnormal findings were recorded.
体内活性	EGT1442在大鼠和犬的稳定尿糖排泄方面表现出有效性，其ED50值分别为0.38 mg/kg和0.09 mg/kg，并且在db/db小鼠中以浓度依赖的方式降低HbA(1c)和血糖水平。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 100 mg/mL (215.08 mM)
关键字	EGT-1442 \| EGT 0001442 \| THR 1442 \| Bexagliflozin \| EGT-0001442 \| THR1442 \| EGT 1442
相关产品	Ipragliflozin \| Empagliflozin \| Dapagliflozin \| Canagliflozin \| Tofogliflozin (hydrate) \| Phloretin \| Sergliflozin A \| Ertugliflozin \| Sotagliflozin \| Ertugliflozin L-pyroglutamic acid \| Dapagliflozin ((2S)-1,2-propanediol, hydrate) \| Phlorizin
相关库	抑制剂库 \| 经典已知活性库 \| 抗癌上市药物库 \| 已知活性化合物库 \| FDA 上市药物库 \| GPCR靶点分子库 \| 膜蛋白靶向化合物库 \| 药物功能重定位化合物库 \| 抗癌临床化合物库 \| 抗癌药物库

THR-1442|||EGT1442|||EGT0001442|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务