托珠单抗|T9911|TargetMol

Tocilizumab
375823-41-9

￥1580 1mg 起订

￥2330 2mg 起订

￥3980 5mg 起订

上海更新日期：2024-09-30

TargetMol中国（陶术生物）

VIP3年

联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 托珠单抗

英文名称：: Tocilizumab

CAS号：: 375823-41-9

品牌：: TargetMol

产地：: 美国

保存条件：: store at -20°C | Shipping with blue ice.

纯度规格：: 99.50%

产品类别：: 抑制剂

货号：: T9911

Product Introduction

Bioactivity

Name	Tocilizumab
Description	Tocilizumab (Anti-Human IL6R) is a neutralizing antibody against human interleukin-6 receptor (IL-6R) that blocks the binding of IL-6 to IL-6R, thereby inhibiting both classical and trans signaling. It can be used to study rheumatoid arthritis and has been suggested as a possible drug for the treatment of severe COVID-19.
Cell Research	Objective: To validate that IL-6 signaling is essential for TAM (tumor-associated macrophages)-enhanced CSC (cancer stem cells) function. Concentrations: 5 μg/ml. Incubation Time: 72 h. Method: For co-culture experiments, 12-well Transwell chambers were used with 2×105 HepG2 or Hep3B cells seeded in the lower chamber one day before co-culture and either 5×105 or 1×106 TAMs added in the upper chamber. Tocilizumab or human IgG antibody were added in indicated experiments to selected wells. After 24 to 72 hours, HCC cells and CD14+ TAM cells were collected separately for analysis. Cells:HepG2 cell lines, TAMs isolated from HCCs (hepatocellular carcinoma)
In vitro	方法：Tocilizumab （Anti-Human IL6R)（0.001–10,000 μg/ml）培养 Ba/F3-gp130-hIL-6R 或 Ba/F3-gp130-mIL-6R 细胞 2 天，观察细胞增殖情况。结果：Tocilizumab （Anti-Human IL6R)可以抑制细胞增殖，IC50值为 13.5 ng/mL。[1]
In vivo	方法：将HARA-B细胞接种到裸鼠心脏的左心室，接种三周后，在接下来的三周内每周静脉注射Tocilizumab （Anti-Human IL6R)（1.0 mg/100 μL，两周一次，三周）。结果：在Tocilizumab （Anti-Human IL6R)注射的小鼠大脑中，每个转移病灶的体积显着较小。[2]
Storage	store at -20°C \| Shipping with blue ice.
Keywords	COVID-19 \| IL-6R \| Anti-Human IL6R, Humanized Antibody \| rheumatoid \| respiratory failure \| antibody \| Interleukin Related \| coronavirus disease \| arthritis \| inhibit \| Tocilizumab \| dyspnoea \| Neutralizing \| Inhibitor
Inhibitors Related	Deucravacitinib \| Sodium Thiocyanate \| Apilimod \| Vidofludimus \| JAK2/STAT3-IN-1 \| Muscone \| Fibrinogen \| SMA-12b \| Apilimod mesylate \| Hydrocortisone hemisuccinate \| Disulfiram \| Balsalazide sodium hydrate

托珠单抗|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务