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  • 化合物 S38093|T4099|TargetMol

化合物 S38093|T4099|TargetMol

S 38093
862896-30-8
￥398 1mg 起订
￥543 2mg 起订
￥747 5mg 起订
上海 更新日期：2024-12-12

TargetMol中国（陶术生物）

VIP3年
联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
化合物 S38093
英文名称：
S 38093
CAS号：
862896-30-8
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格：
99.98%
产品类别：
抑制剂
货号：
T4099

Product Introduction

Bioactivity

名称S 38093
描述S 38093 is a brain-penetrant antagonist of the H3 receptor (Ki: 8.8/1.44/1.2 μM, for rat/mouse/human).
动物实验S 38093 is formulated in purified water.The context discrimination task consists of an 8-day contextual fear discrimination paradigm in which the mice have to learn to distinguish between a fearful shock context and a similar non-shock context. On day 1 the mice are only exposed to the training shock context, and on days 2-8 the mice are exposed to the shock and then non-shock context in that order each day. The mice are run through the context discrimination task starting at 10 am and ending at 2 pm and are then gavaged with vehicle or S 38093 at 4 pm each day. The drug and vehicle are always administered after behavioral testing to avoid possible acute effects of the drug on behavior. Learning is measured by the percent time the mice spent freezing and testing is terminated when percent freezing is consistently significantly different between the two contexts. The mice are tested after 29 days of drug treatment. Conditioning is conducted on one side of a Med-Associates shuttle box (ENV-010MC; 20.3?cm?×?15.9?cm?×?21.3?cm high) with a clear plexiglass wall, 3 aluminum walls and a stainless steel grid as a floor. Mouse behavior is recorded by digital video cameras mounted above the conditioning chamber. In training context A, mice are allowed to habituate in new cages outside the room and are then brought into the room in the new cages. The house fan and house light are turned on, the stainless steel grid is exposed, the plexiglass wall is up and a mild anise scent is used as an olfactory cue. The door to the sound dampening enclosure is shut for the duration of the trial. 180?s after the mice are placed in the training context, they are delivered a single footshock of 0.75?mA lasting 2?s. 15?s after the end of the footshock, the mice are placed back into their home cages. Non-alcoholic antiseptic wipes are used to clean the grids and catch trays in between trials. An hour later the mice are brought into the room in paper buckets and put into similar context B.The house fan and house light are turned off, the door of the enclosure is left ajar, plastic placemat sheets are put into the shuttle box to make a high-walled circular enclosure, the plexiglass wall is left down and a mild lemon scent is used as the olf
体外活性在细胞模型中，S 38093能够拮抗小鼠H3受体(KB: 0.65 μM)，并且能够抑制由H3激动剂引起的cAMP降低(KB: 0.11 μM)。在表达高密度H3受体的细胞中，S 38093对大鼠和人类H3受体表现为中等强度的反向激动作用（EC50: 分别为9/1.7 μM）[2]。
体内活性在年轻成年小鼠中，S 38093（0.3/3 mg/kg/天，口服，28天）显著增加了海马齿状回（DG）内前体细胞的增殖。S 38093（0.3 mg/kg/天）显著增加具有第三级树突的DCX+细胞数量。S 38093（0.3/1/3 mg/kg）显著提高老年小鼠海马DG中细胞的存活、增殖和成熟，相比于对照组。S 38093（3 mg/kg/天，口服，28天）提高了细胞增殖，并对细胞存活产生强烈影响，也增加了两种基因型的树突交叉点，仅在APPSWETG小鼠中从50至80有显著效果。在老年小鼠中，S 38093的长期给药（1/3 mg/kg/天，口服，28天）逆转了这种与年龄相关的BDNF-IX/IV/I转录本的减少。此外，与老龄对照组相比，S 38093在三个测试剂量（0.3/1/3 mg/kg/天）均增加了VEGF转录本[1]。
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 55 mg/mL (190.72 mM)
关键字inhibit | S 38093 | Histamine Receptor | Inhibitor
相关产品Famotidine | Meclizine dihydrochloride | Nizatidine | Lidocaine | Sodium butanoate | Alginic acid | Mirtazapine | Amitriptyline hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Doxepin hydrochloride | Chlorphenesin
相关库抑制剂库 | 经典已知活性库 | 已知活性化合物库 | GPCR靶点分子库 | 膜蛋白靶向化合物库 | 神经退行性疾病化合物库 | 药物功能重定位化合物库 | 疼痛相关化合物库 | 抗癌临床化合物库 | 抗癌药物库
S-38093|||S38093|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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