化合物 MCB613|T6886|TargetMol

MCB-613
1162656-22-5

￥301 1mg 起订

￥458 2mg 起订

￥913 5mg 起订

上海更新日期：2024-09-30

TargetMol中国（陶术生物）

VIP3年

联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 MCB613

英文名称：: MCB-613

CAS号：: 1162656-22-5

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.48%

产品类别：: 抑制剂

货号：: T6886

Product Introduction

Bioactivity

Name	MCB-613
Description	MCB-613 is an effective steroid receptor coactivator (SRC) stimulator.
Cell Research	Cells are seeded in 96-well plates and allowed to reach 60% to 70% confluence. After indicated compound treatments, relative numbers of viable cells are measured by MTS assay using the Cell Titer 96 Aqueous One Solution Cell Proliferation Assay.(Only for Reference)
Kinase Assay	Luciferase assays: After various compound treatments, cells are lysed in luciferase lysis buffer and assayed for luciferase activity using the ONE-Glo luciferase assay system. All luciferase activities are normalized to protein concentration determined by Bradford assay.
In vitro	MCB-613 selectively and reversibly binds to the RID of SRC-3, and selectively kills cancer cells including MCF-7 (breast), PC-3 (prostate), H1299 (lung), and HepG2 (liver) cells, without toxicity to mouse primary hepatocytes and mouse embryonic fibroblasts (MEFs). MCB-613 also increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). [1]
In vivo	In an MCF-7 breast cancer mouse xenograft model, MCB-613 (20 mg/kg, i.p.) significantly and dramatically inhibits the growth of the tumor while causing no obvious animal toxicity and body weight less. [1]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 56 mg/mL (184 mM) DMSO : 56 mg/mL (184 mM)
Keywords	inhibit \| Inhibitor \| MCB613 \| MCB-613
Inhibitors Related	Pelitinib \| Ponatinib \| SI-2 hydrochloride \| Vemurafenib \| Bosutinib hydrate \| KW-2449 \| PD173074 \| TAK-901 \| Staurosporine \| Nintedanib \| Dasatinib \| Ibrutinib
Related Compound Libraries	Angiogenesis related Compound Library \| Bioactive Compound Library \| Anti-Cancer Active Compound Library \| Bioactive Compounds Library Max \| Anti-Cancer Metabolism Compound Library \| Anti-Pancreatic Cancer Compound Library \| Kinase Inhibitor Library \| HIF-1 Signaling Pathway Compound Library \| Tyrosine Kinase Inhibitor Library \| Endoplasmic Reticulum Stress Compound Library

MCB 613|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务