化合物 Vacquinol-1|T7008|TargetMol

Vacquinol-1
5428-80-8

￥1300 1mg 起订

￥2900 5mg 起订

￥4290 10mg 起订

上海更新日期：2024-09-29

TargetMol中国（陶术生物）

VIP3年

联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 Vacquinol-1

英文名称：: Vacquinol-1

CAS号：: 5428-80-8

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 98.67%

产品类别：: 抑制剂

货号：: T7008

Product Introduction

Bioactivity

Name	Vacquinol-1
Description	Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.
Cell Research	Cell viability is measured using CellTiter-Glo Luminescent Cell Viability Assay according to the manufacturer's instructions.(Only for Reference)
Kinase Assay	1MT enantiomers are solubilized in DMSO containing 0.1N HCl and added at concentrations of 100, 50, and 0 μM to wells containing the reaction mixture with tryptophan (0-200 μM) followed by addition of IDO enzyme. Plates are sealed and incubated 1 hr in a humidified 37°C incubator, after which the reactions are terminated by addition of 12.5 μl 30% TCA per well. Plates are then resealed in plastic wrap, incubated 30 min at 50°C to hydrolyze the reaction product N-formylkynurenine to kynurenine, and centrifuged. Supernatants are transferred to a flat-bottom 96-well plate, mixed with 100 μl Ehrlich reagent and incubated 10 min at room temperature. Absorbance at 490 nm is read[1].
In vitro	Vacquinol-1通过诱导膜褶皱、细胞圆化、大量巨大吞噬性空泡累积、ATP耗竭和细胞质膜破裂等机制，特异性快速引发胶质瘤细胞死亡，其IC50值为3.14 μM。[1]
In vivo	在携带U3013 mg肿瘤的小鼠中，Vacquinol-1（15 μM颅内注射，或20 mg/kg经口给药）减缓了肿瘤生长并延长了存活时间。[1]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 70 mg/mL (164.4 mM) Ethanol : < 1 mg/mL (insoluble or slightly soluble)
Keywords	NSC 13316 \| hepatocellular carcinoma \| NSC-13316 \| inhibit \| Inhibitor \| MKK4-specific activator \| Vacquinol1 \| induces apoptosis \| glioblastoma \| glioblastoma multiforme \| HCC \| activates MAPK pathways \| Vacquinol-1 \| NSC13316
Inhibitors Related	Astragaloside IV \| Bentamapimod \| (-)-Bornyl acetate \| Anisomycin \| TCS JNK 5a \| JNK-IN-13 \| (E)-Ferulic acid methyl ester \| SP600125 \| Urolithin B \| SR-3306 \| SKLB-163 \| Ginsenoside Re
Related Compound Libraries	Anti-Cancer Active Compound Library \| Bioactive Compound Library \| Anti-Cancer Compound Library \| Bioactive Compounds Library Max \| Kinase Inhibitor Library \| Anti-Aging Compound Library \| Anti-Obesity Compound Library \| Pain-Related Compound Library

Vacquinol 1|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务