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网站主页 TGFBR1, MOUSE, 重组蛋白 (HFC) TGFBR1, Mouse, 重组蛋白 (hFc)
  • TGFBR1, Mouse, 重组蛋白 (hFc)|TMPJ-01178|TargetMol

TGFBR1, Mouse, 重组蛋白 (hFc)|TMPJ-01178|TargetMol

TGFBR1 Protein, Mouse, Recombinant (hFc)
20200 1mg 起订
上海 更新日期:2026-05-08

TargetMol中国(陶术生物)

VIP3年
联系人:邵小姐
手机:15002134094 拨打
邮箱:marketing@targetmol.cn

产品详情:

中文名称:
TGFBR1, Mouse, 重组蛋白 (hFc)
英文名称:
TGFBR1 Protein, Mouse, Recombinant (hFc)
品牌:
TargetMol
产地:
美国
保存条件:
Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
产品类别:
抑制剂
种属:
Mouse
表达系统:
HEK293 Cells
蛋白长度:
Leu30-Glu125
标签:
C-hFc
货号:
T011|TMPJ-01178

Product Introduction

Bioactivity

名称TGFBR1 Protein, Mouse, Recombinant (hFc)
描述TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII. TGF-beta RI is likely important during development, since mice deficient for TGF-beta RI die at midgestation with severe defects in vascular development of the yolk sac and placenta, and an absence of circulating red blood cells. Furthermore, TGF-beta RI appears to be involved in proper lymphatic network development.
存储条件Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
关键字TGFR1 | TGFR 1 | TGFBR-1 | TGFBR 1 | TGF-b receptor type I | SKR-4 | SKR 4 | ALK5 | ALK 5 | ACVRLK-4 | ACVRLK 4 | AAT-5 | AAT 5
tβR-I;TGFβRI;TGF-β receptor type I;TGFR-1;TGF-bRI;TGFBR1;TGFbetaRI;TGF-beta receptor type I;TGFB1R1;tbetaR-I;SKR4;LDS2A;LDS1A;ALK-5ALK5;ALK-5;ACVRLK4;activin A receptor type II-like kinase, 53kD;AAT5;TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿,致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区,已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库,以及多种类型的生化试剂产品,包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等,此外,我们还建设有CADD(计算机辅助药物设计)研究中心、药理实验室、药化合成平台三大技术中心,全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持,我们将有效帮助您缩短研发周期,取得更成功的结果。

成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ¥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,天然产物,生物化工,化学试剂,生物技术服务

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