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网站主页 化合物 H3R-IN-1 HYDROCHLORIDE 化合物 H3R-IN-1 Hydrochloride
  • 化合物 H3R-IN-1 Hydrochloride|T11531|TargetMol

化合物 H3R-IN-1 Hydrochloride|T11531|TargetMol

H3R-IN-1 Hydrochloride
2319790-07-1
￥10600 25mg 起订
￥13800 50mg 起订
￥17500 100mg 起订
上海 更新日期：2025-11-17

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产品详情:

中文名称：
化合物 H3R-IN-1 Hydrochloride
英文名称：
H3R-IN-1 Hydrochloride
CAS号：
2319790-07-1
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
产品类别：
抑制剂
货号：
T11531

Product Introduction

Bioactivity

名称H3R-IN-1 Hydrochloride
描述H3R-IN-1 Hydrochloride is an inverse agonist of histamine receptor 3( H3R ) .
体外活性Treatment with H3R-IN-1, which is a H3R inverse agonist, promotes oligodendrocyte precursor cell (OPC) differentiation in a dose-dependent manner, at EC 50 =25 nM. Western blot shows a significant increase in expression levels of two markers of mature oligodendrocytes, myelin-associated glycoprotein (MAG) and myeline basic protein (MBP) in differentiating oligodendrocytes after treatment with H3R-IN-1, which reveals that treatment with H3R-IN-1 drives more OPCs to differentiate. H3R-IN-1 increases the Forskolin-stimulated cAMP level in the primary oligodendrocyte precursor cells in a dose-dependent manner [1].
体内活性The ability of H3R-IN-1 to enhance remyelination in vivo is determined using the Cuprizone/Rapamycin-induced demyelination model. Mice are treated with Cuprizone diet combined with intraperitoneal injections of Rapamycin for 5 weeks followed by 9 days of compound administration. Cuprizone diet plus intraperitoneal injections of Rapamycin induced severe demyelination in both corpus callosum and cortex and treatment with H3R-IN-1 (30 mg/kg, 9 days) significantly increases density of myelin specific Black-gold II staining in the lesion of corpus callosum and cortex in forebrain, compared to vehicle control group [1].
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度DMSO : 25 mg/mL (66.16 mM), Sonication is recommended.
关键字HistamineReceptor | Histamine receptor 3 | Histamine Receptor | H3R-IN-1 Hydrochloride | H-3R-IN-1 Hydrochloride | H3RIN1 Hydrochloride | H3R IN 1 Hydrochloride
相关产品Famotidine | Meclizine dihydrochloride | Nizatidine | Lidocaine | Sodium butanoate | Alginic acid | Mirtazapine | Amitriptyline hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Doxepin hydrochloride | Chlorphenesin
H3R-IN-1 Hydrochloride|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (13年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,天然产物,生物化工,化学试剂,生物技术服务

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