化合物 HPOB|T2430|TargetMol

HPOB
1429651-50-2

￥1235 25mg 起订

￥598 10mg 起订

￥374 5mg 起订

上海更新日期：2024-09-29

TargetMol中国（陶术生物）

VIP3年

联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 HPOB

英文名称：: HPOB

CAS号：: 1429651-50-2

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.19%

产品类别：: 抑制剂

货号：: T2430

Product Introduction

Bioactivity

Name	HPOB
Description	HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.
Cell Research	Normal (HFS) and transformed (LNCaP, A549, and U87) cells are cultured with indicated doses of HPOB for 72 h. Five micromolars SAHA is a positive control.Graphs were constructed using Prism 5. (Only for Reference)
Kinase Assay	In Vitro Enzymatic Assay for Histone Deacetylases: In vitro activities of the 11 recombinant human zinc-dependent HDAC enzymes are detected by ?uorigenic release of 7-amino-4-methylcoumarin from substrate upon deacetylase enzymatic activity. A series of dilutions of the unique HDAC6 compound, tubacin, and SAHA are prepared with 10% DMSO in HDAC assay buffer, and 5 μL of the dilution was added to a 50-μL reaction so that the ?nal concentration of DMSO is 1% in all of the reactions. The enzymatic reactions are conducted in duplicate at 37 °C for 30 min in a 50-μL mixture containing HDAC assay buffer, 5 μg BSA, an HDAC substrate, an HDAC enzyme, and a test compound. After enzymatic reactions, 50 μL of 2× HDAC developer is added to each well, and the plate is incubated at room temperature for an additional 15 min. Fluorescence intensity is measured at an excitation of 360 nm and an emission of 460 nm using a Synergy microplate reader. Negative (no enzyme, no inhibitor, a drug with no HDAC inhibition activity) and positive controls (known HDAC inhibitor SAHA) are included in the assays. IC50 is determined at the drug concentration that results in 50% reduction of HDAC activity compared with the control.
In vitro	在负荷CWR22人前列腺癌异种移植物的小鼠体内,HPOB（300 mg/kg/day）与SAHA联用可抑制已生成肿瘤的生长,而单独使用时则无明显抑制作用.
In vivo	在HFS细胞中,HPOB对依托泊苷,阿霉素,或SAHA诱导的转化细胞死亡具有增强作用。在转化细胞中,通过凋亡通路HPOB也会增强依托泊苷诱导的转化细胞死亡。在正常(HFS)和转化的(LNCaP,A549,和U87)细胞中,HPOB诱导α-微管蛋白,但不影响组蛋白,抑制细胞生长,但不影响细胞活性。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : 36 mg/mL (114.5 mM) DMSO : 58 mg/mL (184.5 mM) H2O : < 1 mg/mL (insoluble or slightly soluble)
Keywords	HDAC \| Apoptosis \| cells \| anticancer \| HPOB \| Histone deacetylases \| tumor \| A549 \| U87 \| Inhibitor \| inhibit \| LNCaP \| CWR22 \| selective
Inhibitors Related	Metronidazole \| 5-Fluorouracil \| Curcumin \| Stavudine \| Tributyrin \| Dextran sulfate sodium salt (MW 4500-5500) \| Myricetin \| Sorafenib \| L-Ascorbic acid \| Acetylcysteine \| Sodium 4-phenylbutyrate \| Kaempferol
Related Compound Libraries	Inhibitor Library \| Anti-Breast Cancer Compound Library \| Anti-Cancer Active Compound Library \| Bioactive Compound Library \| Anti-Cancer Compound Library \| Bioactive Compounds Library Max \| Anti-Pancreatic Cancer Compound Library \| Highly Selective Inhibitor Library \| Anti-Aging Compound Library \| Epigenetics Compound Library

HPOB|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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