化合物 GSK0660|T2674|TargetMol

GSK0660
1014691-61-2

￥295 1mg 起订

￥418 2mg 起订

￥672 5mg 起订

上海更新日期：2024-09-29

TargetMol中国（陶术生物）

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联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 GSK0660

英文名称：: GSK0660

CAS号：: 1014691-61-2

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: ≥95%

产品类别：: 抑制剂

货号：: T2674

Product Introduction

Bioactivity

Name	GSK0660
Description	GSK0660 is an antagonist and inverse agonist of PPARβ/δ.
Kinase Assay	Human astrocytoma cells, 1321N1, are grown to stably express rat P2X7, human P2X4, P2X2a, P2X2/3, P2X1, P2Y1?and P2Y2 recombinant receptors. Agonist, BzATP, 2,3-O-(4-ben-zoylbenzoyl)-ATP or ATP-induced changes in intracellular Ca2+?concentrations are assessed in all of the cell lines using the Ca2+?chelating dye, Fluo-4, in conjunction with a Fluorometric Imaging Plate Reader. The cells are plated out the day before the experiment onto poly-D-lysine-coated black 96 well plates. After the agonist addition, changes in intracellular Ca2+ concentrations are recorded, per second, for 3 min. Ligands are tested at 11 half-log concentrations from 10-10 to 10-4 M. BzATP or ATP concentrations corresponds to the EC70?values for each receptor to enable comparison of antagonist potencies across the multiple P2 receptor subtypes. A 438079 is added to the cell plate and ?uorescence data are collected for 3 min before the addition of agonist, subsequently, data are then collected for another 2 min. The pEC50 or pIC50 values are derived from a single curve ?t.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : 4.18 mg/mL (10 mM) DMSO : 50 mg/mL (119.48 mM), Sonication is recommended.
Keywords	inhibit \| PPAR \| Inhibitor \| GSK0660 \| GSK 0660 \| Peroxisome proliferator-activated receptors \| GSK-0660
Inhibitors Related	Icariin \| Fisetin \| Pioglitazone hydrochloride \| Daidzein \| PHYTOL \| 5-Aminosalicylic Acid \| Gemfibrozil \| Fenofibrate \| (S)-(+)-Ibuprofen \| 2,3-Butanediol \| Naringenin \| BADGE
Related Compound Libraries	Lipid Metabolism Compound Library \| Bioactive Compound Library \| Bioactive Compounds Library Max \| Anti-Alzheimer's Disease Compound Library \| Anti-Aging Compound Library \| NO PAINS Compound Library \| Anti-Hypertension Compound Library \| Anti-Obesity Compound Library \| Glycometabolism Compound Library \| Anti-Neurodegenerative Disease Compound Library

GSK0660|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
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