化合物 SF1670|T6667|TargetMol

SF1670
345630-40-2

￥348 1mg 起订

￥491 2mg 起订

￥828 5mg 起订

上海更新日期：2024-12-12

TargetMol中国（陶术生物）

VIP3年

联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 SF1670

英文名称：: SF1670

CAS号：: 345630-40-2

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 98.54%

产品类别：: 抑制剂

货号：: T6667

Product Introduction

Bioactivity

名称	SF1670
描述	SF1670 (PTPase CD45 Inhibitor) is a specific PTEN inhibitor with IC50 of 2 μM.
细胞实验	Cells are plated into 96-well plates in RPMI 1640 medium supplemented with 10% FBS and incubated overnight at 37°C. in an incubator containing an atmosphere of 5% CO2. The following day, the medium is replaced and cells are starved by placing in 100 uL of serum-free medium for 3 hours. Serially diluted test compounds are added to the wells and incubated with the cells for 2 hours at 37°C. Compounds are tested in a range from 1 mM to 0.1 nM depending on solubility. MTT is added to the wells at a final concentration of 5 μg/ml and incubated with the cells for 3 more hours. At the end of the incubation, the medium is aspirated and the MTT stain in the cells is dissolved by the addition of 100 μL DMSO. Optical density of each well is then measured at 570 nm using a SpectroMax Plus spectrophotometric plate reader. The IC50 determination from the data was made using Prism software.(Only for Reference)
激酶实验	PTEN Inhibition Assay: To determine the dose response of potential PTEN inhibitors, doses of test compounds ranging from 1 nM to 250 uM (final reaction mix concentrations) are evaluated in the general PTEN inhibition assay. To obtain performed IC50 data, two separate rounds of the dose response assay are performed. In the first round, PTEN activity is tested in the presence of inhibitor at 10 fold serial dilutions ranging from 1 nM to 250 uM. Once the concentration range is determined, at which PTEN activity changes dramatically, two additional concentration data points within this range are added and the PTEN inhibition assay is then rerun for the second round. The PTEN inhibition IC50 is presented as the inhibitor concentration at which 50% of the PTEN activity. When the assay was run on multiple occasions and gave slightly different IC50 then those are reported as a range of IC50 found.
体外活性	SF1670在HBEC、PC-3、H1299细胞中表现出强烈的细胞毒性，其半抑制浓度(IC50)分别为5 μM、10 μM和44 μM。在小鼠主动脉环Matrigel血管生成模型中，SF1670促进血管生成过程。[1] SF1670增强中性粒细胞对趋化因子诱导的PtdIns(3,4,5)P3信号传导，提高中性粒细胞功能。[2]
体内活性	SF1670 (500 nM i.v.)的预处理能增强中性粒细胞减少症小鼠在腹膜炎和细菌性肺炎中的细菌杀伤能力，并降低与中性粒细胞减少相关的肺炎死亡率。[2]
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 30.7 mg/mL (100 mM)
关键字	SF1670 \| SF 1670 \| inhibit \| Autophagy \| MMAC1 \| Inhibitor \| Phosphatase and tensin homolog \| SF-1670 \| Phosphatase \| PTEN
相关产品	Guanidine hydrochloride \| Naringin \| Stearic acid \| Valproic Acid \| Taurine \| Gefitinib \| Aceglutamide \| Hydroxychloroquine \| Curcumin \| Stavudine \| Paeonol \| Sodium 4-phenylbutyrate
相关库	抑制剂库 \| 经典已知活性库 \| 抗癌化合物库 \| 已知活性化合物库 \| 抗癌细胞代谢库 \| 自噬库 \| 抗衰老化合物库 \| 抗肝癌化合物库 \| 抗氧化化合物库 \| PI3K/Akt/mTOR 化合物库

PTPase CD45 Inhibitor|||PTP CD45 Inhibitor|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务