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  • 化合物 FX1|T4089|TargetMol

化合物 FX1|T4089|TargetMol

FX1
1426138-42-2
￥152 1mg 起订
￥212 2mg 起订
￥373 5mg 起订
上海 更新日期：2024-12-12

TargetMol中国（陶术生物）

VIP3年
联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
化合物 FX1
英文名称：
FX1
CAS号：
1426138-42-2
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格：
98.15%
产品类别：
抑制剂
货号：
T4089

Product Introduction

Bioactivity

名称FX1
描述FX1 is an effective and selective BCL6 inhibitor (IC50: 35 μM).
细胞实验Cell viability is determined with the fluorescent redox dye. Fluorescence is determined for 3 replicates per treatment condition or vehicle with the microplate reader. The drug effect as 100-percentage viability is calculated. Through dose-effect curves the drug concentration that inhibits the growth of cell lines by 50% compared with vehicle (GI50) is determined. Experiments are performed in triplicate. For combination treatments, cells are exposed to a dose curve of each drug alone or their combination in a constant ratio, and cell viability is determined. To compare different schedules of treatments, the cells are treated in triplicate as follows: FX1 and doxorubicin simultaneously and cells treated for 48 hours; FX1 first and 24 hours after doxorubicin is added and treats for an extra 48 hours; doxorubicin first and 24 hours after FX1 is added and treats for an extra 48 hours. Then, the software is used to plot dose-effect curves and calculate the dose-reduction index [1].
动物实验Cell viability is determined with the fluorescent redox dye. Fluorescence is determined for 3 replicates per treatment condition or vehicle with the microplate reader. Cell viability of the drug-treated cells is normalized to their vehicle-treated controls, and the results are expressed as percentage viability. The drug effect as 100-percentage viability is calculated. Through dose-effect curves the drug concentration that inhibits the growth of cell lines by 50% compare with vehicle (GI50) is determined. Experiments are performed in triplicate. For combination treatments, cells are exposed to a dose curve of each drug alone or their combination in constant ratio, and cell viability is determined. To compare different schedules of treatments, the cells are treated in triplicate as follows: FX1 and doxorubicin simultaneously and cells treated for 48 hours; FX1 first and 24 hours after doxorubicin is added and treats for an extra 48 hours; doxorubicin first and 24 hours after FX1 is added and treats for an extra 48 hours. Then, the software is used to plot dose-effect curves and calculate the dose-reduction index[1].
体外活性FX1显著降低了SMRT和BCOR对所有三个BCL6靶基因的招募。在BCL6阴性的DLBCL细胞系中，这些位点几乎不含SMRT，且不受FX1影响。经过50 μM FX1处理6小时后，与79-6相比，FX1在定量ChIP试验中打破BCL6与SMRT结合的优越性在DLBCL细胞的头对头比较中变得明显。
体内活性FX1对总B细胞的丰度没有影响。FX1显著消耗生发中心B细胞（GL7+FAS+B220+）。用B220抗体染色揭示了正常的B细胞滤泡结构，而针对生发中心B细胞特异性标记的花生凝集素染色显示GCs的显著丧失。半衰期估计为大约12小时。与对照组相比，用FX1处理的小鼠固定器官的脾脏、肺、胃肠道、肾、心脏、肝脏和骨髓的H&E染色切片未见毒性、炎症或感染迹象。
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 25 mg/mL (67.79 mM), Sonication is recommended.
关键字inhibit | Apoptosis | Bcl-2 Family | FX-1 | FX1 | FX 1 | Inhibitor
相关产品L-Glutamic acid | Metronidazole | 5-Fluorouracil | Dextran sulfate sodium salt (MW 4500-5500) | Stavudine | Tributyrin | Myricetin | Sorafenib | L-Ascorbic acid | Acetylcysteine | Salicylic acid | Sodium 4-phenylbutyrate
相关库抑制剂库 | 经典已知活性库 | 抗癌化合物库 | 已知活性化合物库 | 转录因子库 | 线粒体靶向库 | 细胞凋亡化合物库 | 抗衰老化合物库 | 高选择性抑制剂库 | PPI抑制剂库
FX1|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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