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网站主页 化合物 TUBULIN POLYMERIZATION-IN-26 化合物 Tubulin polymerization-IN-26
  • 化合物 Tubulin polymerization-IN-26|T61880|TargetMol

化合物 Tubulin polymerization-IN-26|T61880|TargetMol

Tubulin polymerization-IN-26
￥10600 25mg 起订
￥17500 100mg 起订
￥13800 50mg 起订
上海 更新日期：2025-11-17

TargetMol中国（陶术生物）

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邮箱：marketing@targetmol.cn

产品详情:

中文名称：
化合物 Tubulin polymerization-IN-26
英文名称：
Tubulin polymerization-IN-26
CAS号：
2490291-68-2
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
产品类别：
抑制剂
货号：
T61880

Product Introduction

Bioactivity

名称Tubulin polymerization-IN-26
描述Tubulin polymerization-IN-26 (compound 12h) is a chemical compound that inhibits the polymerization of microtubulin. It achieves this by binding to the colchicine binding site of microtubulin, with an IC50 value of 4.64 μM. Additionally, Tubulin polymerization-IN-26 has the ability to induce apoptosis and inhibit cell metastasis or migration. Due to these properties, it holds potential as a valuable compound for researching lung cancer [1].
体外活性Tubulin polymerization-IN-26 (compound 12h) (0.27-30 μM, 48 hours) shows potent cytotoxic activity against lung cancer cells [1]. Tubulin polymerization-IN-26 (compound 12h) (0.1 μM,0.25 μM,0.5 μM, 24 hours) induces cell apoptosis in a dose-dependent manner by promoting ROS production in cells [1]. Tubulin polymerization-IN-26 (compound 12h) (0.1 μM,0.25 μM,0.5 μM, 24 hours) arrests the cell cycle in G2/M phase [1]. Tubulin polymerization-IN-26 (compound 12h) (0.1 μM,0.25 μM,0.5 μM, 24 hours) inhibits microtubule protein polymerization [1]. Cell Cytotoxicity Assay [1] Cell Line: Human non-small cell lung cancer A549, Human triple negative breast cancer MDA-MB-231, Mouse melanoma B16-F10, Human breast cancer BT-474, Mouse triple negative breast cancer 4 T1, Rat kidney epithelial cell line NRK-52E Concentration: 0.27-30 μM Incubation Time: 48 hours Result: Showed cytotoxic activity against A549, MDA-MB-231, B16-F10, BT-474, 4 T1, NRK-52E with IC 50 value of 0.29 μM,1.48 μM,1.25 μM,0.42 μM,0.49 μM,1.58 μM respectively. Apoptosis Analysis [1] Cell Line: Human non-small cell lung cancer A549 Concentration: 0.1 μM,0.25 μM,0.5 μM Incubation Time: 24 hours Result: Changed cell nucleus from normal form to micronucleus with the concentration increasing. Cell Cycle Analysis [1] Cell Line: Human non-small cell lung cancer A549 Concentration: 0.1 μM,0.25 μM,0.5 μM Incubation Time: 24 hours Result: Resulted in more G2/M phase cells production which percentage were 17.6%, 29% and 50.3%, corresponding to concentrations of 0.1 μM, 0.25 μM, and 0.5 μM, respectively. Resulted in even fewer G0/G1 phase cells production which percentage were 41. 1%, 21.2%, and 4.9%, corresponding to concentrations of 0.1 μM, 0.25 μM, and 0.5 μM, respectively.
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
相关产品Sodium citrate | L-Methionine | Gefitinib | Cysteamine hydrochloride | Alginic acid | Metronidazole | Dextran sulfate sodium salt (MW 5000) | Citric Acid Triammonium | Stavudine | Cystamine dihydrochloride | L-Ascorbic acid sodium salt | Sodium 4-phenylbutyrate
Tubulin polymerization-IN-26|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (13年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,天然产物,生物化工,化学试剂,生物技术服务

化合物 Tubulin polymerization-IN-26相关厂家报价

  • 化合物GLP-26
  • 化合物GLP-26
  • 陕西格列弗生物科技研究有限责任公司 VIP
  • 2025-12-25
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