不对称二甲基精氨酸二盐酸盐|T21546|TargetMol

NG,NG-dimethyl-L-Arginine dihydrochloride
220805-22-1

￥218 1mg 起订

￥600 5mg 起订

￥1080 10mg 起订

上海更新日期：2024-12-12

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产品详情:

中文名称：: 不对称二甲基精氨酸二盐酸盐

英文名称：: NG,NG-dimethyl-L-Arginine dihydrochloride

CAS号：: 220805-22-1

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.18%

产品类别：: 抑制剂

货号：: T21546

Product Introduction

Bioactivity

名称	NG,NG-dimethyl-L-Arginine dihydrochloride
描述	NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence[1].
体外活性	NG,NG-dimethyl-L-Arginine (ADMA) was found to be able to inhibit macrophage and vascular NO synthase. When added to a cytosolic preparation of macrophage NO synthase, ADMA could cause dose-dependent inhibition of NO formation. In the presence of added arginine, ADMA could inhibited NO synthesis and the inhibitory effects of ADMA were prevented by addition of L-arginine so that the rate of NO synthesis did not significantly differ from control values [1].
体内活性	Animal study showed that the injection of 1-30 mg/kg ADMA into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. Moreover, during continuous infusion of ADMA, which caused plasma ADMA concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1].
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	Ethanol : 11 mg/mL (39.97 mM) DMSO : 7 mg/mL (25.43 mM) H2O : 14 mg/mL (50.87 mM)
关键字	NG,NG dimethyl L Arginine dihydrochloride \| NG,NG-dimethyl-L-Arginine Dihydrochloride \| NG,NG-dimethyl-L-Arginine \| NG,NGdimethylLArginine dihydrochloride
相关产品	2,4-Diamino-6-hydroxypyrimidine \| Mifepristone \| Methylene Blue \| 2-Ethylpyrazine \| Methylene Blue trihydrate \| Ethyl cinnamate \| L-Arginine hydrochloride \| S-Methylisothiourea sulfate \| L-Arginine \| Aminoguanidine hydrochloride \| L-NAME hydrochloride \| Nitroarginine
相关库	抑制剂库 \| 神经保护化合物库 \| 经典已知活性库 \| 已知活性化合物库 \| NO PAINS 化合物库

不对称二甲基精氨酸二盐酸盐|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

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