化合物 SR9243|T1801|TargetMol

SR9243
1613028-81-1

￥275 2mg 起订

￥452 5mg 起订

￥651 10mg 起订

上海更新日期：2024-09-29

TargetMol中国（陶术生物）

VIP3年

联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 SR9243

英文名称：: SR9243

CAS号：: 1613028-81-1

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.03%

产品类别：: 抑制剂

货号：: T1801

Product Introduction

Bioactivity

Name	SR9243
Description	SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.
Cell Research	Cells are cultured in 96 well plates and treated with designated amounts of SR9243 for 96 hr in media containing 1% FBS and antibiotics. Cell-viability is assessed using the Cell-titre 96 kit according to the manufacturer's guidelines. Cell culture media is supplemented with oleate, stearate and palmitate dissolved in methanol to a concentration of 25 mM. 25 mM stocks are then diluted 10 fold in PBS containing 0.9% BSA. Lipid stocks (100X) are stored at ?20° until needed.(Only for Reference)
Kinase Assay	ALK5 Fluorescence Polarization Binding Assay: GW788388 binding to ALK5 is tested on purified recombinant GST?ALK5 (residues 198-503). Displacement of rhodamine green fluorescently labeled ATP competitive inhibitor by different concentrations of GW788388 is used to calculate a binding pIC50. GST?ALK5 is added to a buffer containing 62.5 mM N-(2-hydroxyethyl)piperazine-N'-2-ethanesulfonic acid (Hepes), pH 7.5, 1 mM dithiothreitol (DTT), 12.5 mM MgCl2, 1.25 mM 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic acid (CHAPS), and 1 nM rhodamine green-labeled ligand so that the final ALK5 concentration is 10 nM based on active-site titration of the enzyme. The enzyme/ligand reagent (40 μL) is added to 384-well assay plates containing 1 μL of different concentrations of GW788388. The plates are read immediately on a LJL Acquest fluorescence reader with excitation, emission, and dichroic filters of 485, 530, and 505 nm, respectively. The fluorescence polarization for each well is calculated by the Acquest and is then imported into curve-fitting software for construction of concentration?response curves.
In vitro	在表达LXRs的HEK293细胞中，SR9243通过增强LXR-核抑制因子的招募来抑制LXR的激活。在多种癌细胞类型中，SR9243降低癌细胞活性，诱导凋亡细胞死亡，并使癌细胞对化疗治疗更加敏感。[1]
In vivo	在Ob/Ob小鼠中，当它们摄入高脂饮食时，SR9243（60 mg/kg, i.p.）抑制了LXR依赖的脂肪生成酶基因表达和肿瘤生长。[1]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 20 mg/mL (31.9 mM), Sonication is recommended.
Keywords	SR-9243 \| LXR \| Liver X receptor \| Inhibitor \| SR 9243 \| SR9243 \| inhibit
Inhibitors Related	(20S)-Protopanaxatriol \| T0901317 \| GW6340 \| Rovazolac \| GSK2033 \| SR9238 \| RGX-104 \| LXR-623 \| BE1218 \| GW3965 hydrochloride \| AZ876 \| GAC0003A4
Related Compound Libraries	Anti-Cancer Active Compound Library \| Bioactive Compound Library \| Anti-Cancer Compound Library \| Bioactive Compounds Library Max \| Bioactive Lipid Compound Library \| Metabolism Compound Library \| NO PAINS Compound Library \| Nuclear Receptor Compound Library \| Anti-Metabolism Disease Compound Library \| PPI Inhibitor Library

SR9243|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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SR 9243, CAS #1613028-81-1
Shanghai Yusheng Medchem Co., Ltd
2018-12-21
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