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网站主页 化合物 TUBULIN POLYMERIZATION-IN-14 化合物 Tubulin polymerization-IN-14
  • 化合物 Tubulin polymerization-IN-14|T60600|TargetMol

化合物 Tubulin polymerization-IN-14|T60600|TargetMol

Tubulin polymerization-IN-14
￥13800 50mg 起订
￥17500 100mg 起订
￥10600 25mg 起订
上海 更新日期：2025-11-17

TargetMol中国（陶术生物）

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联系人：邵小姐
手机：15002134094 拨打
邮箱：marketing@targetmol.cn

产品详情:

中文名称：
化合物 Tubulin polymerization-IN-14
英文名称：
Tubulin polymerization-IN-14
CAS号：
2417134-05-3
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
产品类别：
抑制剂
货号：
T60600

Product Introduction

Bioactivity

名称Tubulin polymerization-IN-14
描述Tubulin polymerization-IN-14 (Compound 20a) is a tubulin polymerization inhibitor (IC 50 = 3.15 μM) that exhibits potent anti-vascular and anticancer activities including cancer cell apoptosis [1].
体外活性Tubulin polymerization-IN-14 (Compound 20a) binds to the colchicine binding site on tubulin [1]. Tubulin polymerization-IN-14 (0-1 μM; 72 h) inhibits cancer cell growth [1]. Tubulin polymerization-IN-14 (5-20 nM; 48 h) arrests K562 cell cycle at G2/M phase, significantly induces cell apoptosis in K562 cells in a concentration-dependent manner, and induces mitochondrial membrane potential (MMP) collapse and mitochondrial dysfunction in K562 cells [1]. Tubulin polymerization-IN-14 (5-20 nM; 24 h) significantly decreases wound closure and capillary-like tubules formation in a concentration-dependent manner in HUVECs [1]. Cell Proliferation Assay [1] Cell Line: K562 cells Concentration: 0-1 μM Incubation Time: 72 h Result: Showed anti-proliferative activity with an IC 50 of 0.01 ± 0.001 μM against K562 cells. Cell Cytotoxicity Assay [1] Cell Line: HepG2, HCT-8, MDA-MB-231 and HFL-1 cells Concentration: 0-1 μM Incubation Time: 72 h Result: Showed cytotoxic activities with IC 50 s of 0.019 ± 0.002, 0.021 ± 0.003, 0.02 ± 0.001 and 0.118 ± 0.007 μM against HepG2, HCT-8, MDA-MB-231 and HFL-1 cells, respectively. Cell Cycle Analysis [1] Cell Line: K562 cells Concentration: 5 nM, 10 nM and 20 nM Incubation Time: 48 h Result: 9.40%, 11.54% and 15.28% of cells were arrested at G2/M phase at 5, 10 and 20 nM, respectively. Apoptosis Analysis [1] Cell Line: K562 cells Concentration: 5 nM, 10 nM and 20 nM Incubation Time: 48 h Result: Compared to the percentage of apoptosis cells in control group (3.25%), the total percentage of the early (Annexin-Vt/PI) and late (Annexin-Vt/PIt) apoptosis cells were 10.46%, 48.55% and 62.26% after being treated at 5, 10, and 20 nM for 48 h, respectively. Cell Migration Assay [1] Cell Line: HUVECs Concentration: 5 nM, 10 nM and 20 nM Incubation Time: 24 h Result: After exposed to compound at 5, 10, and 20 nM for 24 h, cells migrated into 67.6%, 55.3% and 49.2% of the wound area, respectively.
体内活性Tubulin polymerization-IN-14 (Compound 20a) (15 and 30 mg/kg; i.v.; daily for 21 days) displays obvious and dose-dependent antitumor effect with no significant toxicity in the liver tumor allograft mouse model [1]. Animal Model: Five-week-old male ICR mice, liver tumor allograft model [1] Dosage: 15 and 30 mg/kg Administration: Intravenous injection, daily for 21 days Result: The decrease in tumor weight reached 68.7% at doses of 30 mg/kg per day at 21 days after initiation of treatment as compared to vehicle without obvious loss of body weight.
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
相关产品Sodium citrate | L-Methionine | Gefitinib | Cysteamine hydrochloride | Alginic acid | Metronidazole | Dextran sulfate sodium salt (MW 5000) | Citric Acid Triammonium | Stavudine | Cystamine dihydrochloride | L-Ascorbic acid sodium salt | Sodium 4-phenylbutyrate
Tubulin polymerization-IN-14|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (13年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,天然产物,生物化工,化学试剂,生物技术服务

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