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  • UNC2025 hydrochloride|T39474|TargetMol

UNC2025 hydrochloride|T39474|TargetMol

UNC2025 hydrochloride
2070015-17-5
询价 1removed 起订
上海 更新日期：2026-06-29

TargetMol中国（陶术生物）

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联系人：邵小姐
电话：4008200310拨打
手机：15002144251 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
UNC2025 hydrochloride
英文名称：
UNC2025 hydrochloride
CAS号：
2070015-17-5
品牌：
TargetMol
产地：
美国
保存条件：
Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
产品类别：
抑制剂
货号：
T001|T39474

Product Introduction

Bioactivity

名称UNC2025 hydrochloride
描述UNC2025 hydrochloride is a potent, ATP-competitive, highly orally active Mer/Flt3 inhibitor. It has IC50 values of 0.74 nM and 0.8 nM, respectively, for Mer and Flt3. UNC2025 hydrochloride demonstrates over 45-fold selectivity for MERTK compared to Axl (IC50 = 122 nM; Ki = 13.3 nM). Additionally, UNC2025 hydrochloride exhibits excellent PK properties, making it suitable for investigating acute leukemia.
体外活性UNC2025 is against FLT3, MER, AXL, TRKA, TRKC, QIK, TYRO3, SLK, NuaK1, KIT and Met with IC 50 values of 0.35 nM, 0.46 nM, 1.65 nM, 1.67 nM, 4.38 nM, 5.75 nM, 5.83 nM, 6.14 nM, 7.97 nM , 8.18 nM and 364 nM, respectively[1]. UNC2025 (0-60 nM; 1 hour) mediates potent inhibition of Mer phosphorylation with an IC 50 of 2.7 nM?in 697 B-ALL cells[1]. UNC2025 (0-60 nM; 1 hour) results in decreased phosphorylation of Flt3 with an IC 50 of 14 nM in Flt3-ITD positive Molm-14 acute myeloid leukemia cells[1].UNC2025 (3 nM-3 μM; 1 hour) decreases p-MEK, p-AXL, p-TYRO3 expression as a concentration manner in 32D Cells[1]. UNC2025 (14 nM–10 μM; 48 hours) inhibits MERTK signaling and colony-forming potential in a MERTK-expressing patient sample with a 20-fold difference in sensitivity of MERTK-expressing leukemia blasts relative to normal cord or marrow blood mononuclear cells[2].UNC2025 (25-300 nM; 1 hour) mediates potent and dose-dependent decreases in MERTK phosphorylation/activation in both cell lines and inhibition of MERTK correlated with decreased phosphorylation of previously reported MERTK-dependent signaling components STAT6, AKT, and ERK1/2[2]. Western Blot Analysis[1]Cell Line: 32D Cells Concentration: 0 nM, 3 nM, 10 nM, 20 nM, 30 nM, 100 nM, 1000 nM, 3000 nM Incubation Time: 1 hour Result: Inhibited p-MEK, p-AXL, p-TYRO3 expression. Cell Proliferation Assay[1]Cell Line: Mononuclear cells Concentration: 14 nM–10 μM Incubation Time: 48 hours Result: Showed IC 50 values ranged from 9.0 nM to >10 μM with a median IC 50 of 2.38 μM. Western Blot Analysis[2]Cell Line: Kasumi-1 AML and 697 B-ALL cells Concentration: 25-300 nM Incubation Time: 48 hours Result: Decresed p-MERTK, p-STAT6, p- AKT and p-ERK1/2 expression as a dose-dependent manner.
体内活性UNC2025 (intravenous injection or oral adminstration; 3 mg/kg) exhibits an excellent PK properties: low clearance (9.2 mL/min kg), longer half-life (3.8 h), and high oral exposure (100%), it shows T max , C max , and AUClast 0.50 hour, 1.6 μM, and 9.2 h?μM, respectively[2]. UNC2025 (orally adminstration; 50 or 75 mg/kg; 34 and 70 days) mediates a statistically significant dose-dependent reduction in tumor burden relative to vehicle. mediates dose-dependent increases in median survival from 26 days after initiation of treatment in vehicle-treated mice, to 34 and 70 days in mice treated with 50 or 75 mg/kg UNC2025, respectively[2]. Animal Model: NSG mice injected with 697 B-ALL cells[2]Dosage: 50 or 75 mg/kg Administration: Oral adminstration Result: Delayed the disease progression.
存储条件Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
关键字UNC-2025 hydrochloride | UNC2025 Hydrochloride | UNC 2025 Hydrochloride
相关产品Onatasertib | SGI-1776 | Gilteritinib | Fostamatinib | Bleximenib oxalate | Quizartinib | Nintedanib | Sorafenib | Pexidartinib | Sunitinib | Brigatinib | Ripretinib
UNC2025 hydrochloride;TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (14年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

UNC2025 hydrochloride相关厂家报价

  • UNC2025；
  • UNC2025；
  • 上海切尔齐生物科技有限公司
  • 2025-04-07
  • 询价
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