化合物 Bioymifi|T2065|TargetMol

Bioymifi
1420071-30-2

￥249 1mg 起订

￥348 2mg 起订

￥597 5mg 起订

上海更新日期：2025-11-17

TargetMol中国（陶术生物）

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联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 Bioymifi

英文名称：: Bioymifi

CAS号：: 1420071-30-2

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 98.00%

产品类别：: 抑制剂

货号：: T2065

Product Introduction

Bioactivity

名称	Bioymifi
描述	Bioymifi (DR5 Activator) is an effective activator of the TRAIL receptor DR5, binding to the extracellular domain (ECD) of DR5 with a Kd of 1.2 μM. Bioymifi can serve as a novel mimetic of TNF-related apoptosis-induced ligand (TRAIL), inducing DR5 aggregation as a sole inducer, and stimulating cell apoptosis.
细胞实验	Dose-response curves of bioymifi and A2C2 in T98 g cells are plotted as a function of A2C2 or bioymifi concentration. Human glioblastoma (T98 g) cells are treated with various concentrations of A2C2 or bioymifi alone or in combination with 1 μM Smac mimetic (SM) for 48 h. The corresponding cell survival is normalized to the treatment without A2C2 or bioymifi.(Only for Reference)
激酶实验	Solubilized membranes from 3T3 Flk-1 cells are added to polystyrene ELISA plates that has been precoated with a monoclonal antibody that recognizes Flk-1. After an overnight incubation with lysate at 4°C, serial dilutions of SU5416 are added to the immunolocalized receptor. To induce autophosphorylation of the receptor, various concentrations of ATP are added to the ELISA plate wells containing serially diluted solutions of SU5416. The autophosphorylation is allowed to proceed for 60 min at room temperature and then stopped with EDTA. The amount of phosphotyrosine present on the Flk-1 receptors in the individual wells is determined by incubating the immunolocalized receptor with a biotinylated monoclonal antibody directed against phosphotyrosine. After removal of the unbound anti-phosphotyrosine antibody, avidin-conjugated horseradish peroxidase H is added to the wells. A stabilized form of 3,3′,5,5′-tetramethyl benzidine dihydrochloride and Water2 is added to the wells. The color readout of the assay is allowed to develop for 30 min, and the reaction is stopped with H2SO4. Parallel biochemical kinase assays are performed to measure autophosphorylation on EGFR and fibroblast growth factor receptor[1].
体外活性	方法：红细胞用 Bioymifi (10-100 µM) 处理 24 h，通过 flow cytometry 鉴定 Bioymifi 的溶血和杀菌特性及潜在分子机制。结果：Bioymifi 能发挥剂量反应性、钙非依赖性溶血作用，减少红细胞血红蛋白，显著增加膜联蛋白 V、Fluo4 和 DCF 阳性细胞，以及对前向和侧向光散射的双重影响。[1] 方法：新生大鼠心室肌细胞 (nrvm) 用 Bioymifi (10 µM) 处理 24 h，通过 Western Blot 检测靶点蛋白表达水平。结果：Bioymifi 处理的 nrvm 中 DR5 的表达高于 NRVF。[2]
体内活性	方法：为研究 DR5 激活在心脏中的作用，将 Bioymifi (5 mg/kg/d) 微型渗透泵给药给 C57BL/6 小鼠，每天一次，持续两周。结果：Bioymifi 的给药导致心脏器官和心肌细胞水平的肥大，但并不影响心肌细胞的死亡或心脏纤维化。[2]
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	DMSO : 7.5 mg/mL (15.17 mM), Sonication is recommended.
关键字	Tumor Necrosis Factor Receptor \| TNFR \| TNF Receptor \| Inhibitor \| inhibit \| extracellular \| DR5 \| domain \| cells \| caspase-8 \| cancer \| Bioymifi \| Apoptosis \| aggregation
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DR5 Activator|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(13年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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