基本信息 产品详情 公司简介 推荐产品
网站主页 489416-12-8 化合物 ST-193
  • 化合物 ST-193|T13006|TargetMol

化合物 ST-193|T13006|TargetMol

ST-193
489416-12-8
询价 1removed 起订
上海 更新日期:2024-09-29

TargetMol中国(陶术生物)

VIP3年
联系人:邵小姐
手机:4008200310 拨打
邮箱:marketing@tsbiochem.com

产品详情:

中文名称:
化合物 ST-193
英文名称:
ST-193
CAS号:
489416-12-8
品牌:
TargetMol
产地:
美国
保存条件:
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格:
99.67%
产品类别:
抑制剂
货号:
T13006

Product Introduction

Bioactivity

名称ST-193
描述ST-193 is a potent inhibitor of broad-spectrum arenavirus(Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively).
体外活性LASV pseudotypes(IC50 of 1.6 nM)inhibited by ST-193 . ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC50s for Junín, Machupo, Guanarito, and Sabiá were in the 0.2 to 12 nM range)[2].
体内活性ST-193, exhibits submicromolar antiviral activity in vitro.?To determine the antiviral utility of ST-193 in vivo, Tested the efficacy of this compound in the LASV guinea pig model.?Four groups of strain 13 guinea pigs were administered 25 or 80 mg/kg ST-193, 25 mg/kg of ribavirin, or the vehicle by the intraperitoneal (i.p.) route before infection with a lethal dose of LASV, strain Josiah, and continuing once daily for 14 days.?Control animals exhibited severe disease, becoming moribund between days 10 and 15 postinfection.?ST-193-treated animals exhibited fewer signs of disease and enhanced survival when compared to the ribavirin or vehicle groups.?Body temperatures in all groups were elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals.?ST-193 treatment mediated a 2-3-log reduction in viremia relative to vehicle-treated controls.?The overall survival rate for the ST-193-treated guinea pigs was 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups.?These data suggest that ST-193 may serve as an improved candidate for the treatment of Lassa fever[3].
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 150 mg/mL (403.80 mM)
关键字ST193 | inhibit | Inhibitor | Arenavirus | ST 193 | ST-193
相关产品4-Phenylbutyric acid | L-Lysine hydrochloride | Anthraquinone | Probucol | PCL 016 | EIDD-1931 | (-)-α-Pinene | 2-Phenylethanol | (-)-Epicatechin gallate | Phenytoin sodium | Aspirin | Vorinostat
相关库抑制剂库 | 经典已知活性库 | 已知活性化合物库 | 抗感染化合物库 | 抗病毒库
ST-193|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿,致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区,已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库,以及多种类型的生化试剂产品,包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等,此外,我们还建设有CADD(计算机辅助药物设计)研究中心、药理实验室、药化合成平台三大技术中心,全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持,我们将有效帮助您缩短研发周期,取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ¥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

化合物 ST-193相关厂家报价

  • pNPP底物 ST
  • pNPP底物 ST
  • 多睿思特(深圳)医疗科技有限公司
  • 2024-11-11
  • 询价
  • st-Ht31
  • st-Ht31
  • 杭州固拓生物科技有限公司 VIP
  • 2024-11-22
  • 询价
  • ST细胞
  • ST细胞
  • 上海雅吉生物科技有限公司 VIP
  • 2024-11-22
  • ¥1800
内容声明
拨打电话 立即询价