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  • BM-1197|T38810|TargetMol

BM-1197|T38810|TargetMol

BM-1197
1391107-89-3
￥22800 25mg 起订
上海 更新日期：2025-11-17

TargetMol中国（陶术生物）

VIP2年
联系人：邵小姐
手机：15002134094 拨打
邮箱：marketing@targetmol.cn

产品详情:

中文名称：
BM-1197
英文名称：
BM-1197
CAS号：
1391107-89-3
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
产品类别：
抑制剂
货号：
T38810

Product Introduction

Bioactivity

名称BM-1197
描述BM-1197, a highly potent and specific dual inhibitor of Bcl-2 and Bcl-xL, effectively targets these proteins with IC50 values of 3.5 nM and 5.2 nM for Bcl-2 and Bcl-xL, respectively. This compound demonstrates notable antitumor activity in both in vitro and in vivo settings.
体外活性BM-1197 (2-2000 nM; 3 d) has marginal cytotoxicity against wild-type mouse embryonic fibroblast (MEF) cells but exerts potent growth-inhibitory activity in the MCL1 ?/? cells[1]. BM-1197 shows potent growth-inhibitory activities in 7 small cell lung cancer (SCLC) cell lines with IC 50 s <100 nM, moderate activity in 3 SCLC cell lines with IC 50 s of ～600 nM and weak activity in 2 SCLC cell lines with IC 50 s >2000 nM[1]. BM-1197 (100 nM; 16 h) potently induces apoptosis in H146 cells[1]. BM-1197 (100 nM; 2 h) disrupts the association between Bcl-xl and Puma or Bim in H146 cells[1]. BM-1197 (100 nM; 0.5-2 h) induces Bax translocation, and it (3-30 nM; 2 h) induces cytochrome c release in H146 cells[1]. Cell Proliferation Assay[1]Cell Line: MEF/ MCL1 ?/? cells Concentration: 2, 20, 200, 2000 nM Incubation Time: 3 days Result: Inhibited MCL1 ?/? cells proliferation. Apoptosis Analysis[1]Cell Line: H146 cells Concentration: 100 nM Incubation Time: 16 hours Result: Induced apoptosis in a strictly Bax/Bak-dependent manner. Western Blot Analysis[1]Cell Line: H146 cells Concentration: 100 nM Incubation Time: 2 hours Result: Attenuated the associations between Bcl-xL and BimEL or Puma.
体内活性BM-1197 (10 mg/kg; i.v. daily 5 days per week for 2 weeks) results in rapid and complete tumor regression in all 8 mice in H146 and H1963 tumor model[1]. BM-1197 (15 mg/kg; i.v.) causes thrombocytopenia in mice but the effect is reversible even at highly efficacious doses[1]. BM-1197 (10 mg/kg; i.v. qd) exerts a strong anti-tumor effect and is well tolerated in OCI-Ly8 xenograft models[2]. Animal Model: SCID mice bearing H146 cells[1]Dosage: 10 mg/kg Administration: I.v. daily 5 days per week for 2 weeks Result: Remained tumor free for at least 32 days after the end of the treatment.
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
关键字BM-1197 | BM1197 | BM 1197
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BM-1197|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (13年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,天然产物,生物化工,化学试剂,生物技术服务

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