化合物 AQX-016A|T8996|TargetMol

AQX-016A
849669-54-1

￥14900 25mg 起订

￥24625 100mg 起订

￥19420 50mg 起订

上海更新日期：2025-11-17

TargetMol中国（陶术生物）

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联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 AQX-016A

英文名称：: AQX-016A

CAS号：: 849669-54-1

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

产品类别：: 抑制剂

货号：: T8996

Product Introduction

Bioactivity

名称	AQX-016A
描述	AQX-016A is an orally active and potent SHIP1 agonist. AQX-016A is a structural analog of pelorol which is 3 times more potent than the marine natural product pelorol at the same molar concentration. AQX-016A can activate recombinant SHIP1 enzyme in vitro and stimulate SHIP1 activity. AQX-016A also can inhibit the PI3K pathway and TNFa production, can be useful for various inflammatory diseases research [1] [2].
体外活性	AQX-016A (5 μg/mL, 30 min) inhibits the PI3K-mediated increase in intracellular PIP3 levels, and reduces PIP3 levels by activation of a 5 'phosphatase enzyme [1]. AQX-01 6A (0-5 μg/mL, 30 min) inhibits LPS-induced PKB phosphorylation in a SHIP dependent manner [1]. AQX-016A (0-5 μg/mL, 2 h) significantly inhibits TNFa in both J774 and peritoneal macrophages at both 1 and 5 μg/mL [1]. AQX-016A (0-6 μg/mL, 30 min) requires SHIP to maximally inhibit TNFa production in BMDM, selectively inhibits TNF production from SHIP1 +/+ but not SHIP1 -/- macrophages [1]. AQX-016A (0-5 μg/mL, 0-90 min) inhibits TNFa translation [1]. AQX-016A (0-15 μM, 30 min) increases SHIP1 enzyme activity in vitro and in intact cells, inhibits macrophage and mast-cell activation [2]. AQX-016A (15 μM, 30 min) inhibits immune cell activation, and inhibits PI3K-dependent macrophage and mast-cell responses in a SHIP-dependent manner [2]. Western Blot Analysis Cell Line: SHIP1 +/+ and SHIP1 -/- mast cells [2] Concentration: 0, 3, 6, 15, 30 μM Incubation Time: 30 min Result: Inhibited PIP3-regulated intracellular signal transduction events in SHIP-expressing hematopoietic cells, but not in SHIP-deficient hematopoietic or nonhematopoietic cells. Preferentially inhibited, in a dose-dependent manner, LPS-stimulated PKB phosphorylation in SHIP1 +/+ but not in SHIP1 -/- macrophages, and inhibited the phosphorylation of PKB, p38 MAPK and extracellular signal-regulated kinase (ERK) in SHIP1 +/+ but not in SHIP1 -/- mast cells.
体内活性	AQX-016A (20 mg/kg, Orally, once) significantly inhibits plasma TNFa levels and inhibits inflammation in a mouse model of endotoxemia [1] [2].
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
关键字	AQX016A \| AQX 016A \| AQX-016A
相关产品	Sodium orthovanadate \| Ethyl palmitate \| Musk ketone \| Apremilast \| Glucosamine \| Undecane \| β-Glycerophosphate disodium salt hydrate \| Myricetin \| 1,8-Cineole \| Acetylcysteine \| Dodecane \| Isoprenaline hydrochloride

AQX-016A|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(13年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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