化合物 diABZI STING agonist-1 trihydrochloride|T5516|TargetMol

diABZI STING agonist-1 trihydrochloride
2138299-34-8

￥1420 1mg 起订

￥2880 5mg 起订

￥4890 10mg 起订

上海更新日期：2024-12-12

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 化合物 diABZI STING agonist-1 trihydrochloride

英文名称：: diABZI STING agonist-1 trihydrochloride

CAS号：: 2138299-34-8

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.55%

产品类别：: 抑制剂

货号：: T5516

Product Introduction

Bioactivity

Name	diABZI STING agonist-1 trihydrochloride
Description	diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
Animal Research	To evaluate the potential therapeutic effects of systemically administered diABZI STING agonist-1 trihydrochloride, tested the efficacy of intravenously delivered diABZI STING in a syngeneic mouse model of colorectal tumours (CT-26) in BALB/c mice.?We first established the pharmacokinetic profile of STING in BALB/c mice following intravenous injection of 3 mg/kg .?STING exhibited systemic exposure with a half-life of 1.4 h and achieved systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (~200 ng/ml).?Next, we tested an intermittent dosing paradigm in which 1.5 mg/kg STING was injected intravenously on days 1, 4, and 8 in mice with approximately 100 mm^3 subcutaneous CT-26 tumours.?Treatment with STING resulted in significant tumour growth inhibition as measured by tumour volume AUC analysis (P<0.001), and significantly improved survival (P<0.001) with 8 out of 10 mice remaining tumour free at the end of the study on day 43.
In vitro	diABZI STING agonist-1 trihydrochloride 是选择性的干扰素基因刺激受体(STING)激动剂，在人和小鼠中都能发挥作用，其 EC50值分别为 130 和 186 nM。
In vivo	方法：diABZI STING agonist-1 (trihydrochloride) （3mg/kg，静脉注射）在BALB/c小鼠体内，观察小鼠体内的药代动力学谱。结果：diABZI STING agonist-1 (trihydrochloride) 全身性暴露，半衰期为1.4 h，全身性浓度大于小鼠STING的半最大有效浓度(EC50) (200 ng /ml)。[1] 方法：diABZI STING agonist-1 (trihydrochloride) （1.5 mg/kg, 1、4和8天,静脉注射）在皮下CT-26肿瘤的小鼠中,通过肿瘤体积AUC分析。结果：diABZI STING agonist-1 (trihydrochloride) 对肿瘤生长有明显的抑制作用，显著提高了生存率(P<0.001)。[1]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O : 100 mg/mL (104.24 mM), Sonication is recommended. DMSO : 100 mg/mL (104.24 mM), Sonication is recommended.
Keywords	inhibit \| diABZI STING agonist1 trihydrochloride \| MPYS \| diABZI STING agonist-1 trihydrochloride \| ERIS \| diABZI STING agonist-1 Trihydrochloride \| STING \| Inhibitor \| MITA \| diABZI STING agonist-1 \| Stimulator of Interferon Genes \| TMEM173 \| diABZI STING agonist 1 trihydrochloride
Inhibitors Related	Vadimezan \| SR-717 \| ChX710 \| Dazostinag disodium \| C-178 \| C-176 \| MSA-2 \| Cridanimod \| SN-008 \| diABZI STING agonist-1 \| H-151 \| STING activator Compound 53
Related Compound Libraries	Bioactive Compound Library \| Bioactive Compounds Library Max

diABZI STING agonist-1 trihydrochloride|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
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主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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