化合物 Cyclic ADP-ribose|T19253|TargetMol

Cyclic ADP-ribose
119340-53-3

￥9460 1mg 起订

上海更新日期：2024-12-12

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 化合物 Cyclic ADP-ribose

英文名称：: Cyclic ADP-ribose

CAS号：: 119340-53-3

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

产品类别：: 抑制剂

货号：: T19253

Product Introduction

Bioactivity

名称	Cyclic ADP-ribose
描述	Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-mediated endoplasmic reticulum release and extracellular influx caused by the opening of TRPM2 channels.
体外活性	In cells, cyclic ADP ribose (cADPR) plays an important role in the following processes: cell proliferation and differentiation, regulating for example the expansion of mesenchymal stem cells and hematopoietic progenitor cells, neuronal differentiation of PC12 cells and mouse embryonic stem cells Cardiomyocyte differentiation.
体内活性	In mammals, cyclic ADP-ribose (cADPR) plays an important role in the following processes: inflammation and immune response, including neutrophil chemotaxis and T cell activation; smooth muscle cell contraction in arteries and bronchial tubes, involved Hypoxic pulmonary vasoconstriction and the pathogenesis of inflammation / allergic airway diseases; myometrial contractility, which ultimately helps delivery; myocardial cell contraction in adult heart tissue, involved in angiotensin II and β-adrenaline Myocardial hypertrophy and arrhythmia caused by isoproterenol; endocrine and exocrine pancreatic secretion; social behavior of mice, including memory formation and spatial learning, are related to oxytocin secretion and may be related to niacin deficiency. In addition, cyclic ADP-ribose (cADPR) is involved in the activation and fertilization of eggs in seaweeds and sea urchins, early development of sea urchins, abscisic acid signaling in sponges and plants, cell fission in dinoflagellates, and pathogenicity of Toxoplasma gondii.
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
关键字	Cyclic ADPribose \| Cyclic ADP-ribose \| Cyclic ADP ribose
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cADPR|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
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主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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