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网站主页 1140525-25-2 化合物 SB290157 trifluoroacetate
  • 化合物 SB290157 trifluoroacetate|T12851|TargetMol

化合物 SB290157 trifluoroacetate|T12851|TargetMol

SB290157 trifluoroacetate
1140525-25-2
￥223 1mg 起订
￥497 5mg 起订
￥797 10mg 起订
上海 更新日期：2024-09-29

TargetMol中国（陶术生物）

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联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
化合物 SB290157 trifluoroacetate
英文名称：
SB290157 trifluoroacetate
CAS号：
1140525-25-2
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格：
99.89%
产品类别：
抑制剂
货号：
T12851

Product Introduction

Bioactivity

名称SB290157 trifluoroacetate
描述SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).
体外活性SB 290157 is a competitive antagonist of 125I-C3a radioligand binding to rat basophilic leukemia-2H3 cells expressing the human C3aR (RBL-C3aR, IC50 of 200 nM). SB 290157 blocks C3a-induced C3aR internalization in a concentration-dependent manner and C3a-induced Ca2+ mobilization in RBL-C3aR cells and human neutrophils (IC50s of 27.7 and 28 nM, respectively). SB 290157 is selective for the C3aR in that. SB 290157 also inhibits C3a-induced Ca2+ mobilization of RBL-2H3 cells expressing the mouse and guinea pig C3aRs. It potently inhibits C3a-mediated ATP release from guinea pig platelets and inhibits C3a-induced potentiation of the contractile response to field stimulation of perfused rat caudal artery[1].
体内活性Neutrophil recruitment in a guinea pig LPS-induced airway neutrophilia model inhibited by SB 290157 ,SB 290157 decreases paw edema in a rat adjuvant-induced arthritis model[1]. The antagonist is able to reduce joint swelling only at 3 h, and about 50% inhibition of joint swelling is observed with the concentration of 30 mg/kg. The C3 level is significantly decreased at 3 h compared with naive mice showing complement consumption. Furthermore, the C3 activation is observed and increased corresponding to the graded concentration of anti-OVA pAb[2].
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 125 mg/mL (237.41 mM), Sonication is recommended.
关键字SB-290157 trifluoroacetate | SB-290157 Trifluoroacetate | SB290157 trifluoroacetate | SB290157 Trifluoroacetate | SB-290157 | SB290157 | SB 290157 Trifluoroacetate | SB 290157 | Inhibitor | inhibit | Complement System
相关产品Cyclosporin A | C3a Receptor Agonist | CP-289 | Dexamethasone | BCX 1470 hydrochloride | Complement C5-IN-1 | Iptacopan hydrochloride | ADH-503 | 3-Phenoxybenzaldehyde | EG01377 2HCl | Compstatin control peptide acetate | CP-447697
相关库抑制剂库 | 经典已知活性库 | 已知活性化合物库 | NO PAINS 化合物库 | 免疫/炎症分子化合物库
SB290157 trifluoroacetate|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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