司莫地尔 (准外消旋体富马酸盐)|T12880|TargetMol

Semotiadil recemate fumarate
123388-25-0

￥17500 100mg 起订

￥13800 50mg 起订

￥10600 25mg 起订

上海更新日期：2026-04-02

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产品详情:

中文名称：: 司莫地尔 (准外消旋体富马酸盐)

英文名称：: Semotiadil recemate fumarate

CAS号：: 123388-25-0

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

产品类别：: 抑制剂

货号：: T12880

Product Introduction

Bioactivity

名称	Semotiadil recemate fumarate
描述	Semotiadil recemate fumarate is the recemate of Semotiadil fumarate. Semotiadil fumarate is a novel antagonist of vasoselective Ca2+ channel.
体外活性	Semotiadil(1 μM) produces an inhibition of 12.4±9.7% and in a concentration of 10 μM an inhibition of 25±11.0%[1]. At a holding potential of -100 mV, Semotiadil (> or =0.1 μM; dissolved in DMSO) inhibits the ICa in a concentration-dependent manner (IC50=2.0 μM). At a holding potential of -80 mV or -60 mV, the concentration-inhibition curve observed in the presence of Semotiadil is shifted to the left compared with that observed at -100 mV; and Semotiadil shifts the voltage-dependent inactivation curve to the left. The curve for the decay of ICa is fitted with two time constants. Semotiadil (<1 μM) reduces the slow but not the fast time constant. The curve for the recovery from ICa inactivation also consisted of two time constants, and Semotiadil (1 microM) prolongs the slow recovery. Semotiadil dissolved in deionized water more potently inhibits ICa than Semotiadil dissolved in DMSO[2].
体内活性	Semotiadil fumarate is a novel antagonist of benzothiazine calcium, is given alone or in combination with either Enalapril or trichlormethiazide to conscious, spontaneously hypertensive, rats daily for 2 weeks. When given alone, the antihypertensive effects of Semotiadil (10 mg/kg, p.o.) and Enalapril (5 mg/kg, p.o.) first became apparent after the 3rd dose and thereafter the effects appeared to develop daily although this effect had waned by the time of the next dose. Combined daily dosing of Semotiadil, especially with Enalapril, each at relatively low doses may be able to control hypertension in a continuous manner[3].
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
关键字	Semotiadil recemate Fumarate \| CalciumChannel \| Calcium Channel \| Ca2+ channel
相关产品	Nisoldipine \| L-Phenylalanine \| Tricaine methanesulfonate \| Cinchonine \| Magnesium Chloride Hexahydrate \| 2-Nitrobenzoic acid \| 2,4,6-Tri-tert-butylphenol \| Chlorocresol \| L-Ascorbic acid sodium salt \| L-Ascorbic acid \| Quadrol \| Magnesium sulfate

司莫地尔 (准外消旋体富马酸盐)|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(14年)
注册资本	566.265100万人民币
员工人数	100-500人
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主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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