基本信息 产品详情 公司简介 推荐产品
网站主页 化工产品目录 生物化工 抑制剂 丝裂原活化蛋白激酶(MAPK) MEK 抑制剂 SL 327 化合物 SL-327
  • 化合物 SL-327|T2708|TargetMol

化合物 SL-327|T2708|TargetMol

SL327
305350-87-2
153 1mg 起订
198 2mg 起订
322 5mg 起订
上海 更新日期:2024-09-29

TargetMol中国(陶术生物)

VIP3年
联系人:邵小姐
手机:4008200310 拨打
邮箱:marketing@tsbiochem.com

产品详情:

中文名称:
化合物 SL-327
英文名称:
SL327
CAS号:
305350-87-2
品牌:
TargetMol
产地:
美国
保存条件:
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格:
99.74%
产品类别:
抑制剂
货号:
T2708

Product Introduction

Bioactivity

NameSL327
DescriptionSL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.
Kinase AssayThe ligand binding competition assays are performed. Cytosolic cell extracts from Hepa-1 cells are generated by the resuspension of the cell pellets in HEDG buffer [25 mM Hepes, 1 mM EDTA, 1 mM dithiothreitol, and 10% (v/v) glycerol, pH 7.5] containing 0.4 mM leupeptin, 4 mg/mL aprotinin, and 0.3 mM phenylmethylsulfonyl fluoride, homogenization, and centrifugation at 100,000 g for 45 min. Aliquots of the supernatant (120 μg) are incubated at room temperature for 2 h with the indicated concentrations of Pifithrin-α in the presence of 3 nM [3H]TCDD in HEDG buffer. After incubation on ice with hydroxyapatite for 30 min, HEDG buffer with 0.5% Tween 80 is added. The samples are centrifuged, washed twice, resuspended in 0.2 mL of scintillation fluid, and subjected to scintillation counting. Nonspecific binding is determined using a 150-fold molar excess of TCDF and subtracted from the total binding to obtain the specific binding. The specific binding is reported relative to [3H]TCDD alone[2].
In vitro30 mg/Kg SL327明显损害小鼠空间学习记忆.50 mg/kg SL327可以透过血-脑屏障,通过抑制MAPK/ERK磷酸化而抑制条件性恐惧.
In vivoSL327对多种其他包括PKA,PKC或CamKII的激酶没有抑制效果。
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 50 mg/mL (149.1 mM), Sonication is recommended.
Ethanol : 16.8 mg/mL (50 mM)
KeywordsMitogen-activated protein kinase kinase | MEK | inhibit | SL327 | Inhibitor | MAPKK | MAP2K
Inhibitors RelatedLidocaine hydrochloride | Acyclovir | 2,4-D | Guanidine hydrochloride | Folic acid | Resveratrol | 5-Fluorouracil | Temozolomide | Thymidine | Ribavirin | Azelaic acid | Rifampicin
Related Compound LibrariesInhibitor Library | Bioactive Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Fluorochemical Library | Anti-Aging Compound Library | Highly Selective Inhibitor Library | DNA Damage & Repair Compound Library | Tyrosine Kinase Inhibitor Library | Pain-Related Compound Library
SL-327|||SL 327|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿,致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区,已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库,以及多种类型的生化试剂产品,包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等,此外,我们还建设有CADD(计算机辅助药物设计)研究中心、药理实验室、药化合成平台三大技术中心,全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持,我们将有效帮助您缩短研发周期,取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ¥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

化合物 SL-327相关厂家报价 更多

  • 305350-87-2
  • 305350-87-2
  • 成都彼样生物科技有限公司 VIP
  • 2024-11-21
  • 询价
内容声明
拨打电话 立即询价