化合物 LDC-4297 HCl|T4417|TargetMol

LDC-4297 HCl (1453834-21-3(free base))

￥315 1mg 起订

￥592 5mg 起订

￥1010 10mg 起订

上海更新日期：2025-11-17

TargetMol中国（陶术生物）

VIP2年

联系人：邵小姐

手机：15002134094 拨打

邮箱：marketing@targetmol.cn

产品详情:

中文名称：: 化合物 LDC-4297 HCl

英文名称：: LDC-4297 HCl (1453834-21-3(free base))

CAS号：

品牌：: TargetMol

产地：: 美国

保存条件：: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

产品类别：: 抑制剂

货号：: T4417

Product Introduction

Bioactivity

名称	LDC-4297 HCl (1453834-21-3(free base))
描述	LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.
细胞实验	A trypan blue exclusion assay is performed with cultured cells seeded in 24-well plates and incubated with increasing concentrations of antiviral compound LDC4297 (range, 0.1 to 50 μM) for the durations indicated. Cell staining is achieved with 0.1% trypan blue for 10 min at room temperature before the percentage of viable cells is determined by microscopic counting
体外活性	The affinity of LDC4297 for CDK7 proves to be extremely high. Kinase assays performed for CDK1, CDK2, CDK4, CDK6, CDK7, and CDK9 confirms the selective inhibitory activity of LDC4297 for CDK7 in the nano-picomolar range (IC50, 0.13±0.06 nM for CDK7 versus IC50s between 10 nM and 10,000 nM for all other analyzed CDKs). LDC4297 exerts anticytomegaloviral activity. Human cytomegalovirus (HCMV) replication is inhibited by LDC4297 in a concentration-dependent manner with an EC50 value of 24.5±1.3 nM. Inhibition is statistically significant and morphological signs of cytotoxicity only occurrs at concentrations of 3.3 μM or higher. Anti-HCMV activity of LDC4297 is exerted through a multifaceted mode of action that involves an interference with virus-induced Rb phosphorylation. Virus replication is broadly blocked by LDC4297, whereby the antiviral efficacies varied between the viruses used, i.e., strong efficacy for HSV-1 and VZV (EC50s = 0.02 and 0.06 μM, respectively) and intermediate to low efficacy for HSV-2 and EBV (EC50s = 0.27 and 1.21 μM, respectively
体内活性	An analysis of the PK parameters in CD1 mice reveals positive characteristics after oral administration, as demonstrated for a single-dose treatment (100 mg/kg of LDC4297). The half-life (t1/2z) is determined to be 1.6 h, and a time (Tmax) to a mean peak plasma concentration of 1,297.6 ng/mL is reached 0.5 h after administration, with a continued presence of LDC4297 plasma levels for at least 8 h and a bioavailability of 97.7%
存储条件	Pure form: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	DMSO : 60 mg/mL (127.93 mM), Sonication is recommended.
关键字	LDC-4297 HCl (1453834-21-3(free base)) \| LDC4297 HCl (1453834213(free base)) \| LDC 4297 HCl (1453834 21 3(free base)) \| CDK7
相关产品	Seliciclib \| Nimbolide \| Sodium Oxamate \| Abemaciclib methanesulfonate \| Ribociclib \| Palbociclib monohydrochloride \| Abemaciclib \| Olomoucine \| Palbociclib \| GW 441756 \| Dinaciclib \| Ro-3306
相关库	抑制剂库 \| 抗乳腺癌化合物库 \| 经典已知活性库 \| 抗癌化合物库 \| 已知活性化合物库 \| 细胞周期化合物库 \| 抗胰腺癌化合物库 \| 激酶抑制剂库 \| 抗衰老化合物库 \| NO PAINS 化合物库 \| 表型筛选靶点鉴定库

LDC-4297 HCl (1453834-21-3(free base))|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

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