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网站主页 化工产品目录 生物化工 生化试剂 激动剂抑制剂 N-(3-CHLORO-4-METHYLPHENYL)-2-(2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL)HYDRAZINECARBOTHIOAMIDE 化合物 Kobe0065
  • 化合物 Kobe0065|T1876|TargetMol

化合物 Kobe0065|T1876|TargetMol

Kobe0065
436133-68-5
￥152 1mg 起订
￥337 5mg 起订
￥543 10mg 起订
上海 更新日期：2024-09-29

TargetMol中国（陶术生物）

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联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
化合物 Kobe0065
英文名称：
Kobe0065
CAS号：
436133-68-5
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格：
99.58%
产品类别：
抑制剂
货号：
T1876

Product Introduction

Bioactivity

名称Kobe0065
描述Kobe0065 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD; shows potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.
细胞实验NIH 3T3 cells are transfected with pEF-BOS-HA-H-Ras(G12V) or an empty vector and treated with the 2 and 20 μM compound or the vehicle (DMSO) in the presence of 2% FBS for 1 h. Cell lysate is subjected to detection of c-Raf-1 coimmunoprecipitated with an anti-H-Ras antibody and total c-Raf-1 by Western blotting with an anti-c-Raf-1 antibody. Immunoprecipitated H-Ras(G12V) are detected by an anti-HA antibody.(Only for Reference)
激酶实验Determination of lipase activity: For determination of lipase activity, lysates are incubated with a substrate containing radiolabeled [9,10-3H(N)]-triolein. Subsequently, FA are extracted and quantitated by liquid scintilation counting. Data are presented as mean S.D. of triplicate determinations and representative for at least three independent experiments.
体外活性Kobe0065-family compounds bind to Ras?GTP and exhibit antiproliferative activity toward cancer cells carrying the activated ras oncogenes. The compounds efficiently inhibit the interaction of Ras?GTP with their multiple effectors including Raf, PI3K, and RalGDS and a regulator/effector Sos and show rather broad binding specificity toward various Ras family small GTPases, which may account for their higher potency at the cellular level compared with that of the in vitro binding inhibition[1].
体内活性Kobe0065 has antitumor activity. The compound-treated tumors show a prominent increase of apoptotic cells without any significant body weight loss[1].
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度Ethanol : 4.5 mg/mL (10 mM)), Heating is recommended.
DMSO : 20 mg/ml
关键字inhibit | Inhibitor | Ras | Kobe-0065 | Kobe 0065 | Apoptosis | Kobe0065
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相关库抑制剂库 | 经典已知活性库 | 抗癌化合物库 | 已知活性化合物库 | 抗癌细胞代谢库 | 激酶抑制剂库 | 含氟化合物库 | GPCR靶点分子库 | 膜蛋白靶向化合物库 | 疼痛相关化合物库
Kobe0065|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

化合物 Kobe0065相关厂家报价

  • 436133-68-5
  • 436133-68-5
  • 河南威梯希化工科技有限公司 VIP
  • 2024-11-08
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