化合物 Ciproxifan|T6164|TargetMol

Ciproxifan
184025-18-1

￥289 1mg 起订

￥408 2mg 起订

￥736 5mg 起订

上海更新日期：2024-09-29

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 化合物 Ciproxifan

英文名称：: Ciproxifan

CAS号：: 184025-18-1

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 98.00%

产品类别：: 抑制剂

货号：: T6164

Product Introduction

Bioactivity

Name	Ciproxifan
Description	Ciproxifan (FUB-359) is a highly effective and specific histamin H3-receptor antagonist (IC50: 9.2 nM).
Kinase Assay	PPMTase Assays : Synaptosomal membranes of rat brain cerebellum or total membranes of cultured cell lines (100,000 × g pellet) are used for methyltransferase assays in the cell-free systems. Methyltransferase assays are performed at 37°C in 50 mM Tris-HCl buffer, pH 7.4, using 100 μg of protein, 25 μM [methyl-3H]AdoMet (300,000 cpm/nmol), and 50 μM AFC (prepared as a stock solution in DMSO) in a total volume of 50 μL. DMSO concentration in all assays is 8%. Various AFC concentrations are used in several experiments as indicated in the text. Reactions are terminated after 10 min by addition of 500 μL of chloroform:methanol (1:1) with subsequent addition of 250 μL of Water, mixing, and phase separation. A 125-μL portion of the chloroform phase is dried at 40°C, and 200 μl of 1 N NaOH, 1% SDS solution is added. The methanol thus formed is counted by the vapor phase equilibrium method. Typical background counts (no AFC added) are 50-100 cpm, while typical reactions with AFC yield 500-6,000 cpm. Assays are performed in triplicate, and background counts are subtracted. Methylation of endogenous substrates and gel electrophoresis are performed. Protein carboxyl methylation in intact cells is determined using 100 μCi/mL [methyl-3H]methionine. Cells are assayed in near confluent cultures grown in 10-cm plates with 5 mL of labeling medium.
In vitro	Ciproxifan通过Ki为0.5 nM抑制[3H]HA从突触体的释放，并且通过Ki为0.7 nM抑制[125I]碘代氟比昂在大脑H3受体的结合。Ciproxifan在H3受体显示出高亲和性，但在其它受体亚型上表现出较低的表观亲和性，这是通过在孤立器官上进行的功能测试评估的（组胺H1和H2，毒蕈碱M3，肾上腺素能α1D和β1，血清素5-HT1B，5-HT2A，5-HT3和5-HT4）。[1]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : 54 mg/mL (139.75 mM) DMSO : 10 mM
Keywords	inhibit \| Alzheimer's \| histamine H3 \| Inhibitor \| FUB359 \| disorders \| Ciproxifan \| aging \| Histamine Receptor \| FUB 359
Inhibitors Related	Famotidine \| Meclizine dihydrochloride \| Nizatidine \| Lidocaine \| Alginic acid \| Sodium butanoate \| Mirtazapine \| Amitriptyline hydrochloride \| Trazodone hydrochloride \| Mianserin hydrochloride \| Doxepin hydrochloride \| Chlorphenesin
Related Compound Libraries	Anti-Parkinson's Disease Compound Library \| Histamine & Melatonin Receptor-Targeted Compound Library

环丙基[4-[3-(1H-咪唑-4-基)丙氧基]苯基]甲酮马来酸盐|||FUB-359|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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