化合物 Brompheniramine|T60843|TargetMol

Brompheniramine
86-22-6

￥17500 100mg 起订

￥10600 25mg 起订

￥13800 50mg 起订

上海更新日期：2024-09-29

TargetMol中国（陶术生物）

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联系人：邵小姐

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邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 Brompheniramine

英文名称：: Brompheniramine

CAS号：: 86-22-6

品牌：: TargetMol

产地：: 美国

保存条件：: Shipping with blue ice.

产品类别：: 抑制剂

货号：: T60843

Product Introduction

Bioactivity

Name	Brompheniramine
Description	Brompheniramine ((±)-Brompheniramine) is a potent and orally active alkylamine class antihistamine. Brompheniramine is a selective antagonist of histamine H1 receptor (Kd = 6.06 nM). Brompheniramine can be used in the research of allergic rhinitis that has anticholinergic, antidepressant and anesthetic properties. Brompheniramine can block the calcium channels, sodium channels, and hERG channels with IC 50 s of 16.12 μM, 21.26 μM, and 0.90 μM, respectively [1] [2] [3] [4].
In vitro	Brompheniramine (0.1-100 μM) blocks hERG K + channels expressed in CHO cells in a concentration-dependent manner with an IC 50 of 0.90±0.14 μM, and reduced peak tail current amplitude measured at -60 mV (cells are depolarized for 2 s to +20 mV from a holding potential of -80 mV followed by a 3s repolarization back to -60 mV) [3]. Brompheniramine (1, 10 and 100 μM) significantly shortens the APD 50 and depresses the plateau phase on the action potential in guinea pig papillary muscle, as well as slightly prolongs the APD 90 in guinea pig papillary muscle at 10 and 100 μM [3]. Brompheniramine (0.1-100 μM) inhibit the amplitude of the Ca 2+ channel currents in rat ventricular myocytes by 14.1±1.1, 31.1±5.8, 38.0±3.8 and 90.2±3.7% at 0.1, 1, 10 and 100 μM, respectively [3]. Brompheniramine blocks muscarinic cholinergic receptors in human chinese hamster ovary (CHO) cells [4].
In vivo	Brompheniramine (0.3-3 μM; SC, single dosage) induces cutaneous analgesia in rats [1]. Animal Model: Male Sprague-Dawley rats [1] Dosage: 0.3, 0.6, 1.1, 1.5 and 3.0 μM Administration: SC, single dosage Result: Provoked cutaneous analgesia in a dose-dependent manner, with an EC 50 value of 0.66 μM, and induced prolonged analgesic duration.
Storage	Shipping with blue ice.

Brompheniramine|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
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