化合物 I-CBP112|T3969|TargetMol

I-CBP112
1640282-31-0

￥491 1mg 起订

￥713 2mg 起订

￥1370 5mg 起订

上海更新日期：2024-09-29

TargetMol中国（陶术生物）

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联系人：邵小姐

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邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 I-CBP112

英文名称：: I-CBP112

CAS号：: 1640282-31-0

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.1%

产品类别：: 抑制剂

货号：: T3969

Product Introduction

Bioactivity

Name	I-CBP112
Description	I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
Cell Research	I-CBP112 is dissolved in DMSO and diluted with appropriate medium before use. Cells (6000 KG1a and 13000 LNCaP cells/well) are plated in 96-well flat-bottom plates approximately 24 h prior to drug treatment. After 24 h, 10–20% fetal bovine serum-containing medium is replaced with 2.5% serum medium, and cells are treated with I-CBP112 in 0.18% DMSO; 0.18% DMSO is shown to have negligible cell growth effects under the conditions used in our experiments. After being exposed to I-CBP112 for 66 h, cells are subjected to a final concentration of 0.476% [3H]thymidine per well and allowed to proliferate for an additional 6 h (exposure to I-CBP112 for a total of 72 h). Cells are harvested, and the counts of 3H in each well are taken relative to those treated with vehicle alone to quantify the effect of the ligand on proliferation[1].
Kinase Assay	TGase 2 from guinea pig liver is preincubated for 10 min with various concentrations of GK13 or GK921 in 0.1 mL of reaction buffer, with or without 10 mM CaCl2, followed by the addition of 0.4 mL of substrate solution containing 2
In vitro	将人类和小鼠白血病细胞系暴露于I-CBP112后，显著抑制了菌落形成并且促进了细胞分化，而无明显的细胞毒性。I-CBP112对BioMAP原代细胞板的暴露引起了独特的细胞因子和标志蛋白表达反应。I-CBP112显著增强了p300在组蛋白H3K18和H3K23位点的乙酰化作用。I-CBP112使H3K18ac增加约3倍，I-CBP112诱导的CBP在这些相同位点以及H4K5位点的乙酰化也有所增强。I-CBP112激活p300和CBP介导的H3K18乙酰化的EC50值约为2μM。
In vivo	I-CBP112 在体外和体内显著以剂量依赖方式降低了MLL-AF9+ AML细胞的白血病发起潜力。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 55 mg/mL (117.37 mM)
Keywords	I-CBP112 \| Inhibitor \| HATs \| I CBP112 \| inhibit \| I-CBP 112 \| HAT \| ICBP112 \| I-CBP-112 \| Epigenetic Reader Domain \| Histone Acetyltransferase
Inhibitors Related	Bisdemethoxycurcumin \| dBET6 \| 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one \| CeMMEC1 \| (+)-JQ-1 \| Curcumin \| Acetaminophen \| Naphthol AS-E \| J-147 \| ABBV-744 \| Piflufolastat \| Anacardic Acid
Related Compound Libraries	Inhibitor Library \| Bioactive Compound Library \| Bioactive Compounds Library Max \| Chromatin Modification Compound Library \| NO PAINS Compound Library \| Epigenetics Compound Library \| Anti-Hypertension Compound Library \| Hematonosis Compound Library \| PPI Inhibitor Library \| Reprogramming Compound Library

I-CBP112|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

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