12-oxo Leukotriene B4|T37256|TargetMol

12-oxo Leukotriene B4
136696-10-1

￥3880 25μg 起订

上海更新日期：2025-11-17

TargetMol中国（陶术生物）

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联系人：邵小姐

手机：15002134094 拨打

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产品详情:

中文名称：: 化合物 12-oxo Leukotriene B4

英文名称：: 12-oxo Leukotriene B4

CAS号：: 136696-10-1

品牌：: TargetMol

产地：: 美国

保存条件：: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

产品类别：: 抑制剂

货号：: T37256

Product Introduction

Bioactivity

名称	12-oxo Leukotriene B4
描述	12-oxo Leukotriene B4 (12-Oxo-LTB4) is a potent pro-inflammatory lipid mediator classified as a dihydroxy fatty acid that is enzymatically derived from arachidonic acid metabolism via the 5-lipoxygenase (5-LO) pathway, and it promotes a diverse array of leukocyte functional responses including cellular aggregation, stimulation of transmembrane ion fluxes, enhancement of lysosomal enzyme release, superoxide anion generation, chemotaxis, and chemokinesis; 12-oxo Leukotriene B4 is an initial oxidative metabolite formed from Leukotriene B4 via the LTB4 12-hydroxydehydrogenase pathway, which undergoes rapid enzymatic conversion first to 10,11-dihydro-12-oxo-LTB4 followed by reduction of the 12-oxo group to yield 10,11-dihydro-LTB4, and this metabolite exhibits significantly reduced biological potency, being approximately 70-fold less potent than LTB4 in stimulating Ca2+ mobilization in human neutrophils (EC50 = 33 nM vs. 0.46 nM) and also markedly less effective at stimulating neutrophil migration (EC50 = 170 nM vs. 2.7 nM).
存储条件	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	Ethanol : 1 mg/mL (2.99 mM), Sonication is recommended. PBS (pH 7.2) : > 1 mg/mL DMF : 1 mg/mL (2.99 mM), Sonication is recommended. DMSO : 1 mg/mL (2.99 mM), Sonication is recommended.
关键字	12-oxo Leukotriene B-4 \| 12-oxo Leukotriene B4 \| 12oxo Leukotriene B4 \| 12 oxo Leukotriene B4
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12-Oxo-LTB4|TargetMol

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