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  • 荞麦碱|TQ0298|TargetMol

荞麦碱|TQ0298|TargetMol

Fagomine
53185-12-9
￥1670 1mg 起订
上海 更新日期：2024-12-12

TargetMol中国（陶术生物）

VIP3年
联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
荞麦碱
英文名称：
Fagomine
CAS号：
53185-12-9
品牌：
TargetMol
产地：
美国
保存条件：
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格：
98.97%
产品类别：
抑制剂
货号：
TQ0298

Product Introduction

Bioactivity

NameFagomine
DescriptionFagomine (D-Fagomine) is a mild glycosidase inhibitor, an analog of 1-deoxynojirimycin (DNJ) with hypoglycemic activity, and Fagomine reduces intracellular reactive oxygen species (ROS) production and malondialdehyde (MDA) levels.
Cell ResearchHuman skin fibroblasts from a healthy and three Gaucher disease patients (with N188S/G183W, V230G/R296X, and L444P/L444P mutations) are maintained in DMEM supplemented with 10% FBS as the culture medium. For enzyme activity enhancement assay, cells are cultured in the presence of different concentrations of Fagomine or DMSO alone (as a control) for 5 days and harvested by scraping. Cytotoxicity of Fagomine is monitored by measuring the lactate dehydrogenase activities in the cultured supernatants [1].
Kinase AssayLysosomal enzyme activities in cell lysates are determined. Briefly, cells are scraped in ice-cold 0.1% Triton X-100 in water. After centrifugation (6000 rpm for 15 min at 4°C) to remove insoluble materials, protein concentrations are determined using Protein Assay Rapid Kit. The lysates are incubated at 37°C with the corresponding 4-methylumbelliferyl β-D-glycopyranoside solution in 0.1 M citrate buffer (pH 4). The liberated 4-methylumbelliferone is measured with a fluorescence plate reader (excitation 340 nm; emission 460 nm). For enzyme inhibition assay, cell lysates from normal skin fibroblasts are mixed with the 4-methylumbelliferyl β-D-glycopyranoside substrates in the absence or presence of increasing concentrations of Fagomine [1].
Animal ResearchSprague-Dawley rats (male, 22 weeks old) are randomly assigned to one of the three dietary groups: the control group fed a standard diet (STD); a group fed HFHS (modified high-fat high-sucrose diet); a group fed HFHS supplemented with 0.065% Fagomine (HFHS+FG). The percentage of Fagomine is adjusted so that its ratio to sucrose is 2 mg/g, as defined before from the results of post-prandial tests. The modified diets are processed. Feed consumption is monitored every day throughout the experiment and body weight is measured before and at the end of the nutritional intervention. All animal manipulations are carried out in the morning to minimize the effects of circadian rhythms [3].
In vitroFagomine (D-fagomine)，一种次氨基糖，在体外展现出对大肠杆菌的选择性凝集作用。D-fagomine选择性地聚集有鞭毛的大肠杆菌，阻止它们附着于肠道黏膜。这种效果可能归因于其与结合到凝集素（如甘露糖）的糖基团结构相似性。D-fagomine能够改变高脂高糖饮食（HFHS）对肠道内肠杆菌科和拟杆菌属比例的影响[3]。
In vivoFagomine（D-fagomine），一种天然的亚氨基糖，能够抵消高能量密度饮食对体重、空腹血糖水平及肠道肠杆菌属[3]短期影响。与标准组相比，同时摄入D-fagomine的高脂高蔗糖饮食（HFHS）大鼠体重增加显著较低（15.3%），而仅摄入HFHS的大鼠体重增加为20.9%[2]。
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationH2O : 30 mg/mL (203.85 mM)
KeywordsFagomine
Inhibitors RelatedLycopene | Allopurinol | Cannabigerol | Inosine | Baicalein | (±)-Catechin | Tempol | Ethyl cinnamate | Acetylcysteine | Rifamycin S
荞麦碱|||D-Fagomine|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

荞麦碱相关厂家报价

  • 荞麦碱
  • 荞麦碱
  • 上海抚生实业有限公司
  • 2024-09-13
  • 询价
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