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  • 化合物 Lemildipine|T15733|TargetMol

化合物 Lemildipine|T15733|TargetMol

Lemildipine
94739-29-4
￥2120 2mg 起订
￥3160 5mg 起订
￥10600 25mg 起订
上海 更新日期：2025-11-17

TargetMol中国（陶术生物）

VIP4年
联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
化合物 Lemildipine
英文名称：
Lemildipine
CAS号：
94739-29-4
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
产品类别：
抑制剂
货号：
T15733

Product Introduction

Bioactivity

名称Lemildipine
描述Lemildipine is a new blocker of dihydropyridine calcium entry.
体内活性Lemildipine produces a significant decrease in the blood pressure of spontaneously hypertensive rats (SHR). Lemildipine is 1.4 times stronger than Nifedipine; the ED30 values of Lemildipine and Nifedipine are 10.2 mg/kg and 14.3 mg/kg, respectively[2]. Gerbils are treated intraperitoneally with Lemildipine (0.1-3 mg/kg) just after release of the occlusion. Four days after the ischemia, they are fixed by perfusing 10% buffered-formalin, and the neuronal cell density (NCD, cell/mm) in the CA1 subfield is estimated under microscopy. The average NCD in the ischemic control group is 43±10.8 cells/mm, whereas Lemildipine (3 mg/kg) significantly ameliorates DND with an average NCD of 143±24.2 cells/mm (P<0.01). Lemildipine (3-30 mg/kg; p.o.), in normal Wistar rats (NWR), produces a mild lowering of blood pressure. Lemildipine(p.o.; 3, 10, 30 mg/kg) produces a significant decrease in systolic blood pressure dose-dependently. Lemildipine (3 mg/kg) significantly inhibits delayed neuronal death (DND) at 1, 2 and 4 weeks after transient ischemia: the average NCD of the Lemildipine and ischemic control groups are 80±9.4 (P<0.01) and 43±7.7 cells/mm, 92±13.7 (P<0.05) and 52±9.3 cells/mm, and 57±5.0 (P<0.01) and 43±12.4 cells/mm, respectively. Lemildipine shows a protective effect on DND in the hippocampal CA1 subfield after transient forebrain ischemia, in this experiment, and its effect persisted for up to 4 weeks[1]. The maximum decrease is observed 1-3 hr after administration. Comparing the hypotensive potency of Lemildipine and Nifedipine, their dose-response curves at the maximum response during the observation (for 24 hr) are analyzed by the least squares method, and the dose of 30% decrease in blood pressure from the control level (ED30) are used as a measure of their potency.
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
关键字NPK1886 | NPK 1886 | NB818 | NB 818 | Lemildipine | Calcium entry
相关产品L-Phenylalanine | Nisoldipine | Cromolyn sodium | 1-Octanol | Cinchonine | 2-Nitrobenzoic acid | 2,4,6-Tri-tert-butylphenol | Otilonium bromide | Ethyl cinnamate | L-Ascorbic acid sodium salt | L-Ascorbic acid | Methyl homoveratrate
NPK-1886|||NB-818|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (13年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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