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  • 化合物 OICR9429|T6916|TargetMol

化合物 OICR9429|T6916|TargetMol

OICR-9429
1801787-56-3
279 1mg 起订
393 2mg 起订
632 5mg 起订
上海 更新日期:2024-12-12

TargetMol中国(陶术生物)

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联系人:邵小姐
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邮箱:marketing@tsbiochem.com

产品详情:

中文名称:
化合物 OICR9429
英文名称:
OICR-9429
CAS号:
1801787-56-3
品牌:
TargetMol
产地:
美国
保存条件:
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格:
99.93%
产品类别:
抑制剂
货号:
T6916

Product Introduction

Bioactivity

名称OICR-9429
描述OICR-9429 is a potent antagonist of the interaction that WDR5 effect with peptide regions of MLL and Histone 3. It reduces the viability of acute myeloid leukemia cells in vitro.
细胞实验20,000 viable, actively proliferating primary human AML cells per well were seeded in 96-well plates in triplicates and treated with 0.05% DMSO or OICR-9429. Cell viability was measured using the Cell Titer-Glo luminescent cell viability assay on a VICTOR X4 luminometer after 72 h.(Only for Reference)
激酶实验AR binding affinity: AR binding affinities of test compounds are studied in cytosolic lysates obtained from ventral prostates of castrated rats by a competition binding assay. Fresh prostates are minced and homogenized with Buffer A containing protease inhibitors. The homogenates are centrifuged and the resultant supernatants are treated with a dextran-coated charcoal solution to remove endogenous steroids. The dissociation constant of the radio ligand [3H]mibolerone for isolated rat ARs is determined in a saturation binding experiment. For the determination of Ki values, prostate cytosol preparations and 1?nM [3H]mibolerone are incubated with increasing concentrations of test compounds overnight. After the incubation, bound and free steroids are separated by treatment with 100?μL of dextran-coated charcoal suspension. Bound radioactivity is determined by counting 100?μL of supernatant fraction in 200?μL of scintillation fluid using a microbeta counter. All procedures are carried out at 0–4?°C.
体外活性OICR-9429以高亲和性结合WDR5(Kd=93±28 nM),并竞争性地干扰其与MLL中高亲和性Wdr5-interacting (WIN) 肽的相互作用(Kdisp=64±4 nM)[1]。
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 50 mg/mL (89.99 mM)
Ethanol : 12 mg/mL (21.6 mM)
关键字pancreatic | Histone Methyltransferase | MLL | inhibit | colon | prostate cance | OICR9429 | bladder cancer (BCa) | OICR-9429 | Inhibitor | WD repeat domain 5 (WDR5) | Apoptosis | leukaemia | H3K4
相关产品JAK-IN-10 | Tofacitinib Citrate | Deucravacitinib | MRTX-1719 | Tazemetostat | iso-Azalansta | EPZ015666 | Fedratinib | Ruxolitinib phosphate | Delgocitinib | MAK-683 hydrochloride | Piribedil
相关库抑制剂库 | 经典已知活性库 | 抗癌化合物库 | 已知活性化合物库 | 激酶抑制剂库 | 细胞凋亡化合物库 | 抗衰老化合物库 | 抗COVID-19化合物库 | 抗肺癌化合物库 | 表型筛选靶点鉴定库
OICR 9429|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿,致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区,已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库,以及多种类型的生化试剂产品,包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等,此外,我们还建设有CADD(计算机辅助药物设计)研究中心、药理实验室、药化合成平台三大技术中心,全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持,我们将有效帮助您缩短研发周期,取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ¥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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