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  • 化合物 AUT1|T5183|TargetMol

化合物 AUT1|T5183|TargetMol

AUT1
1311136-84-1
￥322 1mg 起订
￥787 5mg 起订
￥1180 10mg 起订
上海 更新日期：2024-12-12

TargetMol中国（陶术生物）

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联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
化合物 AUT1
英文名称：
AUT1
CAS号：
1311136-84-1
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格：
99.80%
产品类别：
抑制剂
货号：
T5183

Product Introduction

Bioactivity

名称AUT1
描述AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).
细胞实验The population patch-clamp mode of an automated voltage clamp recording with IonWorks Quattro was used. Briefly, the effects on these channels were tested using 384-well population patch-clamp plates. Seal resistance was measured for each well, and cells were perforated by incubation with 100 mg/ml amphotericin B. Cells were held at 270 mV and stepped to 215 mV for 100 milliseconds (partial channel activation), and after 100 milliseconds at 270 mV, a second pulse to 140 mV was applied for 50 milliseconds (full channel activation). In all of the experiments, this voltage protocol was applied to cells before and following a 3-minute incubation with AUT1. 1-Cyclohexyl-1-[(7,8-dimethyl-2-oxo-1H-quinolin-3-yl)methyl]-3-phenylurea (10 mM), which we had previously found to be a potent and full activator of human Kv3.1 and Kv3.2 channels, was included in all assays as a standard. An external buffer with the addition of dimethyl sulfoxide (DMSO) was also tested to provide a vehicle baseline. Recordings were performed in the following buffers: Dulbecco's phosphate-buffered saline (PBS) with MgCl2 and CaCl2 as an extracellular solution and 50 mM KCl, 100 mM K-gluconate, 3.2 mM MgCl2, and 5 mM HEPES, pH 7.3 adjusted with KOH, as an intracellular solution. An online correction of 115–20 mV was applied to correct for junction potentials. The current signal was sampled at 10 kHz [1].
体外活性AUT1增强了人类重组Kv3.1b和Kv3.2a通道介导的电流。对于Kv3.1b和Kv3.2a，AUT1的pEC50值分别为5.33（4.7 μM）和5.31（4.9 μM）[1]。使用稳定表达大鼠Kv3.1通道的中国仓鼠卵巢细胞，较低浓度的AUT1可将Kv3.1电流的激活电压向负电位移动，从典型神经元静息电位引起的去极化所诱发的电流增加[2]。
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 250 mg/mL (732.36 mM)
关键字Kv3.1b | corticolimbic circuits | AUT1 | inhibit | dysfunction | Potassium Channel | recombinant human Kv3 channels | human recombinant | KcsA | schizophrenia | AUT 1 | AUT-1 | Inhibitor | Kv3.2a
相关产品Cloperastine hydrochloride | Quinine sulfate dihydrate | Minoxidil | 2,2,2-Trichloroethanol | Minoxidil sulfate | Tetraethylammonium bromide | Indapamide | Ursodeoxycholic acid | (±)-Naringenin | Butamben | Halothane | Hydrochlorothiazide
相关库经典已知活性库 | 抗癌化合物库 | 已知活性化合物库 | 钾通道分子库 | NO PAINS 化合物库 | 离子通道库 | 膜蛋白靶向化合物库 | 疼痛相关化合物库
AUT1|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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