| 名称 | Thymohydroquinone |
| 描述 | Thymohydroquinone (Thymoquinol) is a monoterpenoid phenolic compound found in thyme, oregano, and other plants in the labiaceae family. Thymohydroquinone inhibits cancer cell growth, reduces oxidative stress and modulates inflammatory responses, scoured 2, 2-diphenyl-1-PicrylHydrazyl radicals in a cell-free assay (IC50 = 2.4 μg/ml), In the oxygen radical absorption capacity (ORAC) test at concentrations of 1.6 to 6.4 μg/ml, Its Trolox value was 2.6. Thymus hydroquinone inhibited the growth of A2780, OVCAR-8 and CIS-A2780 ovarian cancer cells (IC50 were 3.1, 8.9 and 9.8 μM, respectively) and human ovarian immortalized epithelial cells (IC50 = 14 μM). It also inhibited Plasmodium falciparum in vitro (IC50 = 15.9 μM). |
| 体外活性 | Thymohydroquinone，来源于Nigella sativa种子的一种醌化合物，展现了多种生物活性。该化合物通过cell-free测定对DPPH自由基具有强大的清除作用（IC50 = 2.4 μg/ml）。此外，在氧自由基吸收能力（ORAC）测定中，thymohydroquinone以1.6至6.4 μg/ml的浓度测试，表现出2.6的Trolox等效值。[1]Thymohydroquinone还能抑制A2780、OVCAR-8和CIS-A2780卵巢癌细胞（IC50分别为3.1、8.9和9.8 μM）及永生化人卵巢上皮细胞的生长（IC50 = 14 μM）。2 同时，该化合物对体外培养的P. falciparum也有活性（IC50 = 15.9 μM）。[2] |
| 体内活性 | Thymohydroquinone (THQ) 的抗肿瘤效果通过在两种小鼠肿瘤模型，即纤维肉瘤 (FsaR) 和鳞状细胞癌 (SCC VII) 上的体内评估进行了研究。THQ 的抗肿瘤效应是通过比较接受4次肿瘤内注射，每次剂量为5 mg/kg 的THQ处理的动物与对照组动物的肿瘤生长动态来评估的。体外研究表明，THQ 显示出统计学上显著的剂量依赖性细胞毒活性（p < 0.01），并且这种细胞毒活性对肿瘤细胞的影响比对L929成纤维细胞的影响更为明显。THQ 的体内抗肿瘤活动评价结果显示，肿瘤生长抑制（TGI）为52%，且该效果具有统计学意义（p < 0.05）。[3] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | Ethanol:PBS (pH 7.2) (1:9) : 0.1 mg/mL (0.6 mM), Sonication is recommended.
DMSO : 0.9 mg/mL (5.41 mM), Sonication is recommended.
Ethanol : 1.8 mg/mL (10.83 mM), Sonication is recommended.
DMF : 1 mg/mL (6.02 mM), Sonication is recommended.
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| 关键字 | Thymohydroquinone | ReactiveOxygenSpecies | Reactive Oxygen Species | Antioxidant |
| 相关产品 | Allopurinol | L-Cystine | Kaolin | Dimethyl phthalate | Inosine | Sodium 2-oxopropanoate | Cysteamine hydrochloride | Ethoxyquin | Copper Sulfate Pentahydrate | L-Ascorbic acid sodium salt | L-Ascorbic acid | Ethyl linoleate |
| 相关库 | 抗癌活性化合物库 | 经典已知活性库 | 已知活性化合物库 | 植物来源化合物库 | 抗衰老化合物库 | 抗癌天然产物库 | 天然产物库 | 中药单体化合物库 | 免疫/炎症分子化合物库 | 抗寄生虫库 | 中药抗炎分子库 | 抗感染天然产物库 |
