| Name | Barnidipine hydrochloride |
| Description | Barnidipine hydrochloride (YM-09730-5 hydrochloride) is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery |
| Animal Research | Forty-one patients (mean age 69 ± 17 years, 18 females) with previously diagnosed OSA (by reduced channel home-based polysomnography) who were not being treated with continuous positive airway pressure (CPAP) because of contraindications or because of patient intolerance or rejection were evaluated. Non-dipper status was defined as the presence of a nighttime fall in systolic blood pressure (BP) which was < 10% that of daytime systolic BP as observed in a previous ambulatory blood pressure (ABP) monitoring. OSA was defined according to the presence of 5 or more episodes per hour of apnoea, hypopnoea or arousal due to respiratory effort. The reproducibility of non-dipping status was confirmed through a second 24-h ABP monitoring performed at baseline. On top of the previous stable treatment regimen (which excluded calcium-channel blockers), a 10 mg dosing of barnidipine hydrochloride at bedtime was added to all subjects during a 12-week period[2]. |
| In vivo | Barnidipine通过降低外周血管阻力来展现其降血压活性。在每日口服1和3 mg/kg的剂量下，能够降低自发性高血压大鼠的血压[1]。含有Barnidipine的制剂已被用作治疗高血压。在有阻塞性睡眠窒息症并且是非dipper型高血压的患者中，Barnidipine能够降低夜间平均收缩压和舒张压[2]。 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 250 mg/mL (473.48 mM)
|
| Keywords | Calcium Channel | Barnidipine hydrochloride | Mepirodipine | Ca2+ channels | inhibit | Barnidipine | Inhibitor | Ca channels | Barnidipine Hydrochloride | YM-09730-5 Hydrochloride |
| Inhibitors Related | 1-Octanol | Ethyl cinnamate | L-Ascorbic acid |
| Related Compound Libraries | Neuroprotective Compound Library | Bioactive Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Membrane Protein-targeted Compound Library | Pain-Related Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library |
