化合物 XMD8-87|T3709|TargetMol

XMD8-87
1234480-46-6

￥289 1mg 起订

￥668 5mg 起订

￥1150 10mg 起订

上海更新日期：2024-09-29

TargetMol中国（陶术生物）

VIP3年

联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 XMD8-87

英文名称：: XMD8-87

CAS号：: 1234480-46-6

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 97.61%

产品类别：: 抑制剂

货号：: T3709

Product Introduction

Bioactivity

Name	XMD8-87
Description	XMD8-87 (ACK1-B19) is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mutations found in solid tumor types.
Cell Research	293T cells expressing TNK2 are plated in 6-well format at a density of 250,000 cells per well 48 hours prior to treatment. Cells are then treated with a 100 μL of XMD8-87 or XMD16-5 at 5 μmol/L and with 9 1:1 serial dilutions down to ≈10 nmol/L. Two additional samples are treated with DMSO only. Cells are then incubated for 6 hours at 37°C. Protein extraction is accomplished by adding 300 μL of lysis buffer to cells after removing media. Plates are gently shaken for 5 minutes at room temperature. Lysates are collected and cleared of incompletely solubilized material by spinning for 10 minutes at maximum speed in a microcentrifuge. Samples are prepared for SDS-PAGE using the EPage loading buffer.(Only for Reference)
Kinase Assay	Kinase targets are tested with biochemical enzymatic kinase assays using the SelectScreen Kinase Profiling Service to determine IC50 values. The compounds (XMD8-87) are assayed at 10 concentrations (3-fold serial dilutions starting from 1 μM) at an ATP concentration equal to the ATP Km[1].
In vitro	XMD8-87 在抑制TNK2磷酸化方面显示出高效能。XMD8-87 和 XMD16-5 强效抑制在实体肿瘤类型中发现的TNK2截断突变的磷酸化。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 5.33 mg/mL (11.97 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 5 mg/mL (11.2 mM)
Keywords	Tyrosinase \| XMD8-87 \| Inhibitor \| inhibit \| XMD8 87 \| XMD-8-87 \| XMD887
Inhibitors Related	Oxyresveratrol \| Icariin \| Daidzein \| PHYTOL \| 5-Aminosalicylic Acid \| Fenofibrate \| 2,3-Butanediol \| Potassium iodide \| Naringenin \| 2-Ketoglutaric acid \| Methyl cinnamate \| Hexylresorcinol
Related Compound Libraries	Inhibitor Library \| Bioactive Compound Library \| Bioactive Compounds Library Max \| Transcription Factor-Targeted Compound Library \| Kinase Inhibitor Library \| Anti-Diabetic Compound Library \| Anti-Aging Compound Library \| Protease Inhibitor Library \| DNA Damage & Repair Compound Library \| Tyrosine Kinase Inhibitor Library

ACK1-B19|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
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