化合物 PXS-4787|T60296|TargetMol

PXS-4787

￥28500 25mg 起订

￥59400 100mg 起订

￥33100 50mg 起订

上海更新日期：2025-11-17

TargetMol中国（陶术生物）

VIP2年

联系人：邵小姐

手机：15002134094 拨打

邮箱：marketing@targetmol.cn

产品详情:

中文名称：: 化合物 PXS-4787

英文名称：: PXS-4787

CAS号：: 2409963-50-2

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

产品类别：: 抑制剂

货号：: T60296

Product Introduction

Bioactivity

名称	PXS-4787
描述	PXS-4787 is a potent and selective inhibitor of lysyl oxidase (LOX) with broad-spectrum activity. It effectively suppresses lysyl oxidase activity by acting on its mechanisms. The compound displays inhibitory effects with IC50 values of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4), respectively [1].
体外活性	Lysyl oxidases stabilize collagen which is the main component of scar tissue, and drive scar stiffness and appearance [1]. PXS-4787 (0-10 μM; 15 min-4 h) dose- and time-dependently inhibits lysyl oxidase and displays comparable inhibitory activity across species [1]. PXS-4787 (0-100 μM; 72 h) is well tolerated by primary human dermal fibroblasts, (10 μM; 11 d) reduces collagen formation, deposition and crosslinking in primary human dermal fibroblasts cultured in vitro [1]. PXS-4787 (10 μM; 48 h) induces differential gene expression in fibroblasts and keratinocytes, including COL1A1, LOX, GAPDH, PGK1 [1]. Immunofluorescence [1] Cell Line: Primary human dermal fibroblasts cultured in vitro Concentration: 0, 1, 10 μM Incubation Time: 11 days Result: Significantly reduced in the 10 μM treatment group. RT-PCR [1] Cell Line: Cultured fibroblasts and keratinocytes (isolated from five different patients) Concentration: 10 μM Incubation Time: 48 hours Result: Resulted four genes with significant differential expression in fibroblasts and two differentially expressed genes in keratinocytes.
体内活性	PXS-4787 (3%, oil in water cream; external application; once daily, for 28 days) lowers collagen deposition and cross-linkin in murine models of injury and fibrosis under topical application [1]. PXS-4787 (3%, oil in water cream; external application; once daily, for 12 weeks) also significantly improves scar appearance without reducing tissue strength in porcine injury models under topical application [1]. Animal Model: Porcine excision injury model (female Juvenile pigs, 18-20 kg) [1] Dosage: 3%, oil in water cream; 400 mg cream applied to 16 cm 2 Administration: External application; 1, 2 and 3 weeks post-injury; once dailly, for 12 weeks Result: Improved the appearance of scar in relevant in vivo models, indicative of a targetdriven, as opposed to compound-specific, effect.
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
相关产品	Amitraz \| hMAO-B-IN-32 \| β-Aminopropionitrile \| Safinamide \| Rosmarinic acid \| 1,4-Naphthoquinone \| Hydroxylamine hydrochloride \| Methylene Blue \| Isatin \| J-147 \| Paeonol \| Indazole

PXS-4787|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(13年)
注册资本	589.8595万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	中间体,天然产物,生物化工,化学试剂,生物技术服务

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