化合物 FIN56|T4066|TargetMol

FIN56
1083162-61-1

￥237 1mg 起订

￥336 2mg 起订

￥527 5mg 起订

上海更新日期：2024-12-12

TargetMol中国（陶术生物）

VIP3年

联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 FIN56

英文名称：: FIN56

CAS号：: 1083162-61-1

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.78%

产品类别：: 抑制剂

货号：: T4066

Product Introduction

Bioactivity

名称	FIN56
描述	FIN56 is a specific inducer of ferroptosis.
细胞实验	1000 cells/36 μL are seeded in each well in 384-well plates. Lethal compounds are dissolved and a 2-fold, 12-point dilution series are prepared in DMSO. Compound solutions are further diluted with media at 1:25 and 4 μL/well of the diluted solutions are added to cell cultures immediately after cells are seeded. When ferroptosis inhibitors (100 μM α-tocopherol, 152 μM deferoxamine, or 10 μM U-0126) are co-treated with lethal inducers, they are supplemented to cell culture at the same time as lethal compounds are added, and the cells are incubated for 24 hrs. When other cell death modulating compounds (100 nM sodium selenite, 1 μM cerivastatin, 100 μg/mL mevalonic acid) are co-treated, they are first supplemented to cell culture for 24 hrs before lethal compounds are added to cell culture and further incubated for 24 hrs at 37°C under 5% CO2. On the day of the viability measurement, 10 μL/well of 50% Alamar Blue diluted in media is added and further incubated at 37°C for 6 hrs. Fluorescence intensity (ex/em: 530/590) is measured with a Victor 3 plate reader and the normalized viability is calculated by VL = (IL-I0)/(IV-I0), where VL, I0, IV, and IL are the normalized viability, raw fluorescence intensities from the wells containing media, cells treated with a vehicle (negative control), and cells with the lethal compound (L), respectively. When the effect of a chemical modulator (M) on L is calculated, we instead used the equation: VL\|M = (IM, L-I0)/(IM, V-I0), where VL\|M, IM, L and IM, V are the normalized viability, and fluorescence intensity from cells treated with M and V, and from cells with M and L. respectively. The viability is typically measured in biological triplicates unless otherwise specified. A representative dose-response curve, the mean and standard error of normalized viability from one replicate are plotted.
体外活性	FIN56通过调节GPX4蛋白的丰度来触发铁死亡。它导致细胞裂解物中GPX4活性的丧失。通过过表达GFP-GPX4融合蛋白，可以抑制FIN56引起的细胞死亡。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 50 mg/mL (96.59 mM)
关键字	inhibit \| GPX4 \| Ferroptosis \| degradation \| FIN 56 \| Inhibitor \| squalene \| FIN56 \| FIN-56 \| synthase
相关产品	L-Cystine \| Coenzyme Q10 \| L-Glutamic acid \| L-Glutamic acid monosodium salt \| Artemisinin \| Curcumin \| α-Vitamin E \| Butylated hydroxytoluene \| L-Glutamine \| Sorafenib \| Acetylcysteine \| TBHQ
相关库	经典已知活性库 \| 已知活性化合物库 \| 细胞周期化合物库 \| 细胞凋亡化合物库 \| NO PAINS 化合物库 \| 抗COVID-19化合物库 \| 铁死亡化合物库

FIN56|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务