化合物 INH154|T11657|TargetMol

INH154
1587705-63-2

￥496 1mg 起订

￥1230 5mg 起订

￥1880 10mg 起订

上海更新日期：2024-12-12

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 化合物 INH154

英文名称：: INH154

CAS号：: 1587705-63-2

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.57%

产品类别：: 抑制剂

货号：: T11657

Product Introduction

Bioactivity

名称	INH154
描述	INH154 is a potent Nek2 and Hec1 binding (INH) inhibitor with IC50s of 120 nM in MB468 cells and 200 nM in Hela cells for INH.
体外活性	INH154 also suppresses the growth of leukemia, osteosarcoma, and glioblastoma cells.INH154 is highly potent in treating breast tumors with co-elevated expression of Hec1 and Nek2. INH154 is the most potent inhibitor of tumor cell growth. The IC50 values of INH154 in HeLa and MDA-MB-468 cancer cells are 0.20 and 0.12 μM, respectively.
体内活性	Tumor growth in mice treated with INH154 was significantly slower than in control animals in a dose-dependent manner. Consistent with tumor growth data, residual tumors treated with INH154 had significantly lower tumor proliferation index compared to vehicle alone. The expression levels of Nek2 and Hec1 S165 phosphorylation were also significantly reduced in INH154-treated tumors compared with vehicle-treated tumors. On the other hand, the body weight of the mice was measured during the 6.5-week treatment period, and there was little difference between the treated and control groups[1].
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 65 mg/mL (165.6 mM), Sonication is recommended. H2O : < 0.1 mg/mL (insoluble)
关键字	INH-154 \| inhibit \| Inhibitor \| INH154 \| INH 154
相关库	抑制剂库 \| 经典已知活性库 \| 已知活性化合物库

INH154|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
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主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务