富马酸比索洛尔/Bisoprolol Fumarate/104344-23-2/四川青木/GMP/CEP/Written Confirmation

产品描述

等级：活性药物成分（API）

化学名称：1-（4-{[2-（1-甲基乙氧基）乙氧基]甲基}苯氧基）-3-[（1-甲基乙基）氨基]2-丙醇(2E)- 2-烯二酸酯（2:1）（盐）

分子式:C40H66N2O12

分子量:766.96

规格:ChP / USP / EP / BP / JP

外观:粉

总杂质：不大于0.5%

纯度：不低于99%

残留溶剂：完全符合ICH Q3C要求

致突变杂质：完全符合ICH M8

亚硝胺评估：可用

粒度：可根据客户要求进行普通级或研磨/筛分。

储存方法：室温

生产能力：商用

标准包装：1kg/袋，5kg/袋，或根据客户要求

产品用途

富马酸比索洛尔是富马酸盐的合成苯氧基-2-丙醇衍生的心脏选择性β -1肾上腺素能受体拮抗剂，具有抗高血压和潜在的心脏保护活性。Ÿ   

比索洛尔是一种心脏选择性β1-肾上腺素能阻滞剂，用于治疗高血压。它被认为是一种半衰期长的强效药物，可以每天使用一次，以减少对多剂量降压药的需求。比索洛尔通常耐受性良好，可能是由于其β1-肾上腺素能受体的选择性，是治疗高血压的非选择性β受体阻滞剂（如卡维地洛和拉贝他洛）的有用替代品。它可以单独使用或与其他药物联合使用来控制高血压，并且由于其受体选择性，可用于慢性阻塞性肺疾病（COPD）患者。

近年来，富马酸比索洛尔也被用于治疗心力衰竭。对于先前接受过ACE抑制剂、利尿剂和心糖苷类药物（射血分数≤35%）并伴有心室收缩功能障碍的中重度慢性稳定型心力衰竭患者有效。

联系方式

四川青木制药有限公司

四川省眉山市东坡区经济开发区东区顺江大道南段55号

国际营销部(International):

Email: sales@eastonpharma.cn 

Tel: 028-87827187

国内营销部(Mainland)：

李经理 13880480517   

杨经理 15982276454

Product Description

·       Grade: Active Pharmaceutical Ingredient(API)

·       Chemical Name:1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol (2E)-but-2-enedioate (2:1) (salt)

·       Molecular Formula:C40H66N2O12

·       Molecular Weight:766.96

·       Specification: ChP/USP/EP/BP/JP

·       Appearance: Powder

·       Total impurities: not more than 0.5%

·       Purity: not less than 99%

·       Residual Solvents: fully comply with ICH Q3C

·       Mutagenic impurities: fully comply with ICH M8

·       Nitrosamine assessment: available

·       Particle size: regular grade or milling/sieving according to customer’s requirement.

·       Storage: Room temperature

·       Production capacity: Commercial

·       Standard Package: 1kg/bag, 5kg/bag, or according to the customer’s requirement

Applications of Bisoprolol Fumarate

·       Bisoprolol Fumarate is the fumarate salt of a synthetic phenoxy-2-propanol-derived cardioselective beta-1 adrenergic receptor antagonist with antihypertensive and potential cardioprotective activities.

·       Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure. It is considered a potent drug with a long half-life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity, and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as Carvedilol and Labetalol. It may be used alone or in combination with other drugs to manage hypertension and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.

·       In recent years, Bisoprolol fumarate has also been used to treat heart failure. It is effective in patients with moderate-to-severe chronic stable heart failure who have previously received ACE inhibitors, diuretics, and cardioside drugs (ejection fraction ≤35%) with ventricular systolic dysfunction. 

Contact Information

Sichuan Qingmu Pharmaceutical Co., Ltd.

Add: No. 55, South Shunjiang Avenue, East Economic Development Zone, Dongpo District, Meishan City, Sichuan, 620036, China

International Marketing Department: 

Email: sales@eastonpharma.cn 

Tel: 0086-28-87827187